Publications associées à Protéinopathie

A centrifugation-based physicochemical characterization method for the interaction between proteins and nanoparticles

Nanomedicine requires in-depth knowledge of nanoparticle-protein interactions. These interactions are studied with methods limited to large or fluorescently labelled nanoparticles as they rely on scattering or fluorescence-correlation signals. Here, we hav ...

Nature Publishing Group2016

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

Vassily Hatzimanikatis, Julien Racle, Joana Raquel Pinto Vieira

Understanding the mechanisms behind translation and its rate-limiting steps is crucial for both the development of drug targets and improvement of heterologous protein production with many biotechnological applications, such as in pharmaceutical and biofue ...

Elsevier2016

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

Vassily Hatzimanikatis, Julien Racle, Joana Raquel Pinto Vieira

Elsevier2016

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

Hilal Lashuel, Patrick Fraering, Saviana Di Giovanni, Simona Eleuteri

Aβ accumulation plays a central role in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that the process of Aβ nucleated polymerization is essential for Aβ fibril formation, pathology spreading and toxicity. Therefore, targeting this p ...

2015

Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein

Hilal Lashuel, Klodjan Stafa, Simona Eleuteri

Parkinson's disease (PD) is a common neurodegenerative disorder. Functional interactions between some PD genes, like PINK1 and parkin, have been identified, but whether other ones interact remains elusive. Here we report an unexpected genetic interaction b ...

2015

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein

Hilal Lashuel, Bruno Claude Daniel Fauvet

Posttranslational modifications (PTMs) serve as molecular switches for regulating protein folding, function, and interactome and have been implicated in the misfolding and amyloid formation by several proteins linked to neurodegenerative diseases, includin ...

2015

Detection of Alzheimer’s disease amyloid-beta plaque deposition by deep brain impedance profiling

Philippe Renaud, Patrick Fraering, Amélie Barbara Hildegarde Béduer, Sébastien Mosser, Pierre Joris

OBJECTIVE: Alzheimer disease (AD) is the most common form of neurodegenerative disease in elderly people. Toxic brain amyloid-beta (ASS) aggregates and ensuing cell death are believed to play a central role in the pathogenesis of the disease. In this study ...

Iop Publishing Ltd2015

Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect

Pierre Magistretti, Luc Pellerin

Epidemiological and biochemical studies show that the sporadic forms of Alzheimer's disease (AD) are characterized by the following hallmarks: (a) An exponential increase with age; (b) Selective neuronal vulnerability; (c) Inverse cancer comorbidity. The p ...

Frontiers Research Foundation2015

The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein

Maurizio Molinari

Although the accumulation of a misfolded and protease-resistant form of the prion protein (PrP) is a key event in prion pathogenesis, the cellular factors involved in its folding and quality control are poorly understood. PrP is a glycosylated and disulfid ...

Amer Soc Biochemistry Molecular Biology Inc2015

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Protéinopathie

A centrifugation-based physicochemical characterization method for the interaction between proteins and nanoparticles

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein

Detection of Alzheimer’s disease amyloid-beta plaque deposition by deep brain impedance profiling

Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect

New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods

The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein

Graph Chatbot

Chattez avec Graph Search

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

A centrifugation-based physicochemical characterization method for the interaction between proteins and nanoparticles

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein

Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect

New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods

The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein