Concept

Lipid polymorphism

Publications associées (72)

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Monitoring Membrane Lipidome Turnover by Metabolic N-15 Labeling and Shotgun Ultra-High-Resolution Orbitrap Fourier Transform Mass Spectrometry

Yury Tsybin, Konstantin Nagornov, Kristina Srzentic

Lipidomes undergo permanent extensive remodeling, but how the turnover rate differs between lipid classes and molecular species is poorly understood. We employed metabolic N-15 labeling and shotgun ultra-high-resolution mass spectrometry (sUHR) to quantify ...

Amer Chemical Soc2017

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Three-dimensional (3D) phospholipid monolayers at hydrophobic surfaces are ubiquitous and found in nature as adiposome organelles or in man-made materials such as drug delivery systems. However, the molecular level understanding of such monolayers remains ...

American Chemical Society2017

Planar Optical Nanoantennas Resolve Cholesterol-Dependent Nanoscale Heterogeneities in the Plasma Membrane of Living Cells

Jürgen Brugger, Pamina Winkler, Valentin Flauraud, Raju Regmi

Optical nanoantennas can efficiently confine light into nanoscopic hotspots, enabling single-molecule detection sensitivity at biological relevant conditions. This innovative approach to breach the diffraction limit offers a versatile platform to investiga ...

2017

Pre-transition effects mediate forces of assembly between transmembrane proteins

Berend Smit

We present a mechanism for a generic, powerful force of assembly and mobility for transmembrane proteins in lipid bilayers. This force is a pre-transition (or pre-melting) effect for the first-order transition between ordered and disordered phases in the m ...

Elife Sciences Publications Ltd2016

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Variations between the inner and outer leaflets of cell membranes are crucial for cell functioning and signaling, drug–membrane interactions, and the formation of lipid domains. Transmembrane asymmetry can in principle be comprised of an asymmetric charge ...

American Chemical Society2016

The effects of globotriaosylceramide tail saturation level on bilayer phases

Julian Charles Shillcock

Globotriaosylceramide (Gb(3)) is a glycosphingolipid present in the plasma membrane that is the natural receptor of the bacterial Shiga toxin. The unsaturation level of Gb(3) acyl chains has a drastic impact on lipid bilayer properties and phase behaviour, ...

Royal Soc Chemistry2015

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With proper control over copolymer design and solvation conditions, self-assembled materials display impressive morphological variety that encompasses nanoscale colloids as well as bulk three-dimensional architectures. Here we take advantage of both hydrop ...

Amer Chemical Soc2015

Ligand Coupling Symmetry Correlates with Thermopower Enhancement in Small-Molecule/Nanocrystal Hybrid Materials

Wendy Lee Queen, Michele Kotiuga

The authors study the impact of the coupling symmetry and chem. nature of org.-inorg. interfaces on thermoelec. transport in Cu2-xSe nanocrystal thin films. By coupling ligand-exchange techniques with layer-by-layer assembly methods, the authors are able t ...

2014

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We performed 1H MRS at 14.1T in the liver of GLUT2-/- and wild-type (WT) mice. Improved spectral resolution allowed identifying peaks from the lipid resonances, choline containing compounds, taurine and glycogen in WT mice. Performing the same measurements ...

2014

Interplay of Packing and Flip-flop in Local Bilayer Deformation. How Phosphatidylglycerol Could Rescue Mitochondrial Function in a Cardiolipin-deficient Yeast Mutant

Anne-Florence Raphaëlle Bitbol, Mohammad Rahimi

In a previous work, we have shown that a spatially localized transmembrane pH gradient, produced by acid micro-injection near the external side of cardiolipin-containing giant unilamellar vesicles, leads to the formation of tubules that retract after the d ...

Elsevier BV2014