Concept
Sequence logo
Publications associées (32)
The Role of Conserved Residues in the DEDDh Motif: the Proton-Transfer Mechanism of HIV-1 RNase H
RNase H is a prototypical example for two-metalion catalysis in enzymes. An RNase H activity cleaving the ribonucleic acid (RNA) backbone of a DNA/RNA hybrid is present not only in important drug targets, such as the HIV-1 reverse transcriptase, but also i ...
2021Microfluidic iMITOMI platform to study the architecture of low-affinity transcription factor binding site clusters
Gene regulatory networks (GRNs) determine cellular behaviour, and ultimately the functioning of single- and multicellular organisms. Transcription factors regulate gene expression by binding to DNA or via remodelling chromatin. Recent advances in biotechno ...
EPFL2020Influence of the stacking sequence on the low-energy impact resistance of flax/PA11 composite
In this paper, the low-energy impact behavior of a fully biobased composite made of bio-sourced polyamide 11 resin reinforced with flax fibers was investigated. Different composite laminates were studied in order to determine the stacking sequence effects ...
SAGE PUBLICATIONS LTD2019Distribution of the ribosome associated endonuclease Rae1 and the potential role of conserved amino acids in codon recognition
We recently identified a novel ribonuclease in Bacillus subtilis called Rae1 that cleaves mRNAs in a translation-dependent manner. Rae1 is a member of the NYN/PIN family of ribonucleases and is highly conserved in the Firmicutes, the Cyanobacteria and the ...
TAYLOR & FRANCIS INC2018Spatial organization of DNA sequences directs the assembly of bacterial chromatin by a nucleoid-associated protein
Giovanni Dietler, Aleksandre Japaridze, Sylvain Renevey
Structural differentiation of bacterial chromatin depends on cooperative binding of abundant nucleoid-associated proteins at numerous genomic DNA sites and stabilization of distinct long-range nucleoprotein structures. Histone-like nucleoid-structuring pro ...
American Society for Biochemistry & Molecular Biology (ASBMB)2017Assessing Recent Selection and Functionality at Long Noncoding RNA Loci in the Mouse Genome
Long noncoding RNAs (lncRNAs) are one of the most intensively studied groups of noncoding elements. Debate continues over what proportion of lncRNAs are functional or merely represent transcriptional noise. Although characterization of individual lncRNAs h ...
Oxford Univ Press2015Text Line Detection and Transcription Alignment: A Case Study on the Statuti del Doge Tiepolo
Frédéric Kaplan, Fouad Slimane, Andrea Mazzei
In this paper, we propose a fully automatic system for the transcription alignment of historical documents. We introduce the ‘Statuti del Doge Tiepolo’ data that include images as well as transcription from the 14th century written in Gothic script. Our tr ...
2015Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides
Christian Heinis, Inmaculada Rentero Rebollo, Vanessa Baeriswyl, Michal Sabisz
High-throughput sequencing was previously applied to phage-selected peptides in order to gain insight into the abundance and diversity of isolated peptides. Herein we developed a procedure to efficiently compare the sequences of large numbers of phage-sele ...
Oxford Univ Press2014Improving Bicyclic Peptide Phage Display and Development of Sortase A Inhibitors
Bicyclic peptide ligands are promising molecules for the development of new therapeutics. They combine advantages from large protein therapeutics and small molecule drugs. Large combinatorial libraries of bicyclic peptides can be generated and screened by ...
EPFL2014Phage display libraries of differently sized bicyclic peptides
Christian Heinis, Inmaculada Rentero Rebollo, Alessandro Angelini
Phage selections with combinatorial libraries of uniformly sized bicyclic peptides have recently yielded potent and selective binders of several protein targets. In this work we varied in a combinatorial fashion the ring sizes of bicyclic peptides in phage ...
Royal Soc Chemistry2013