Concept
Pharmacophore
Publications associées (24)
Cyclic Peptides for Drug Development
Christian Heinis, Xinjian Ji, Alexander Lund Nielsen
Cyclic peptides combine a number of favorable properties that make them attractive for drug development. Today, more than 40 therapeutics based on cyclic peptides are in use, and new, powerful technologies for their development suggest that this number cou ...
2024Palladium-based supramolecular assemblies: from complex structures to water-soluble anion-receptors
The combination of palladium salts and bipyridyl ligands can lead to the formation of a large variety of coordination complexes, with different shapes and sizes, displaying a very versatile host-guest chemistry. Increasing their structural complexity remai ...
EPFL2024Multiple Surface Site Three-Dimensional Structure Determination of a Supported Molecular Catalyst
Moreno Lelli, Pierrick Berruyer, David Benjamin Roger Antoine Gajan, Zhuoran Wang
The structural characterization of supported molecular catalysts is challenging due to the low density of active sites and the presence of several organic/organometallic surface groups resulting from the often complex surface chemistry associated with supp ...
AMER CHEMICAL SOC2022Protein Engineering for Personalized therapy and diagnosis
Protein Engineering, especially protein post-translational modification (PTM), ex-tends proteomes in a more complex way than one can expect from analysis of their encod-ing genomes. It can activate or deactivate certain catalytic functions, add new desired ...
EPFL2022Synthesis of New Indole and Adamantane Amido Derivatives with Pharmacological Interest
The synthesis and preliminary pharmacological evaluation of new indole and adamantane amido derivatives is described. The design was based on the pharmacophoric properties of 4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl), 6-[4-(trifluoro methoxy)phenyl ...
WILEY-V C H VERLAG GMBH2019New proposal for production of bioactive compounds by supercritical technology integrated to a sugarcane biorefinery
François Maréchal, Adriano Viana Ensinas
The construction of a supercritical fluid extraction (SFE) plant inside or in close proximity to a sugarcane biorefinery producing first and second generation ethanol demonstrated to be very promising, increasing the economic potential of the SFE process i ...
Springer Verlag2014