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Over the last century, the level of atmospheric CO2 has increased to the highest concentrations on Earth within the past 800'000 years. Current predictions anticipate that the effects of greenhouse gases will lead to a rise in air temperature ranging betwe ...
DNA fragmentation is an essential process in developing genetic sequencing strategies, genetic research, as well as for the diagnosis of diseases with a genetic signature like cancer. Efficient on-chip DNA fragmentation protocols would be beneficial to pro ...
Modern biology rapidly generates a wealth of data,which can only be analysed computationally.Despite the variety of available data types,most of them aim to provide an answer to one question: how does genotypic diversity translates into phenotypes? This qu ...
The rhythmic and sequential segmentation of the vertebrate body axis into somites during embryogenesis is governed by a multicellular, oscillatory patterning system called the segmentation clock. Despite many overt similarities between vertebrates, differe ...
We tackle modelling and inference for variable selection in regression problems with many predictors and many responses. We focus on detecting hotspots, that is, predictors associated with several responses. Such a task is critical in statistical genetics, ...
Objective Primary Sjogren's syndrome (SS) is the second most frequent systemic autoimmune disease, affecting 0.1% of the general population. To characterize the molecular and clinical variabilities among patients with primary SS, we integrated transcriptom ...
A synthesis of the PhD research work on the New Forms of Dwelling (Nuove Forme dell'Abitare), this article traces a short genealogy of the knowledge worker vis-à-vis the history of communal housing. The text discusses three case studies: the campus type, t ...
The focus of the work presented in this thesis is the exploration of the genetic architecture of complex human traits - at the dawn of genomic medicine.The underlying mechanisms explaining the enormously polygenic nature of most human complex traits are ...
Overweight and obesity are increasingly common public health issues worldwide, leading to a wide range of diseases from metabolic syndrome to steatohepatitis and cardiovascular diseases. While the increase in the prevalence of obesity is partly attributabl ...
In this study, we investigated an interdisciplinary project-based learning program. Students were confronted with interdisciplinary challenges in the form of complex and authentic problems, like building a racing car or making a mobile laboratory for genet ...