Concept
Lead compound
Personnes associées (14)
Stewart Cole
Professor Stewart Cole is an international authority in bacterial molecular-genetics and genomics. He has made outstanding contributions in several fields including: bacterial anaerobic electron transport; genome analysis of retroviruses and papillomaviruses; antibiotic resistance mechanisms; and the molecular microbiology of toxigenic clostridia. His studies on isoniazid and multidrug resistance in Mycobacterium tuberculosis, together with his pioneering work on the pathogenicity, evolution and genomics of the tubercle and leprosy bacilli, have made him an undisputed leader in the field of mycobacterial research. The findings of his research are of direct relevance to public health and disease-control in both the developing world and the industrialised nations. He has published over 250 scientific papers and review articles, and holds many patents.
Paul Joseph Dyson
Paul Dyson rejoignit l’EPFL en 2002 à la tête du Laboratoire de chimie organométallique et médicinale de l’Institut des sciences et ingénierie chimiques, dont il en assuma ensuite la direction entre 2008 et 2016.
Le prof. Dyson a été récompensé par de nombreux prix dont le Prix Werner de la Société Suisse de Chimie en 2004, le Prix pour les réalisations exceptionnelles en chimie bio organométallique en 2010, la Médaille du Centenaire de la naissance de Luigi Sacconi (2011) de la Société Italienne de Chimie, le Prix de Chimie bio-inorganique de la Royal Society of Chemistry en 2015, le Prix européen pour une chimie durable de la Société Européenne de Chimie en 2018 et le Prix pour la chimie verte de la Royal Society of Chemistry en 2020.
Le prof. Dyson est également mentionné dans la liste établie par Clarivate des chercheurs les plus cités (Clarivate Highly Cited Researcher), avec un H-index >110 (Web of Science et Google Scholar). Paul Dyson a été élu membre de la Royal Société de Chimie en 2010, membre de l’Académie Européenne des Sciences en 2019 et membre à vie de l’Association Américaine pour l’Avancement de la Science en 2020. Au cours des dernières années il s’est vu décerner le titre de Professeurs Hôte par l’Université de Bourgogne, l’Université de Pierre et Marie Curie, l’Université de Vienne, l’Université de Rome Tor Vergara, l'Ecole Nationale Supérieure de chimie de Paris (Chimie ParisTech) et par l’Université de Shangai Jiao Tong.
De 2016 à 2021 il était membre du conseil de la recherche de la division de mathématique, sciences naturelles et de l’ingénieur du Fonds National Suisse. En 2021, il a été nommé doyen de la Faculté des Sciences de Base.
Sandro Carrara
Sandro Carrara a été nommé IEEE Fellow pour ses remarquables réalisations dans le domaine de la conception de biocapteurs CMOS à l'échelle nanométrique. Il a également reçu le prix "IEEE Sensors Council Technical Achievement Award" en 2016 pour son leadership dans le domaine émergent du co-design des interfaces Bio/Nano/CMOS. Il est un Professeur titulaire à l' EPFL à Lausanne (Suisse) et responsable du groupe de recherche "Bio/CMOS Interfaces" (BCI). Il est ancien professeur de biocapteurs optiques et électriques au Département de génie électrique et de biophysique (DIBE) de l'Université de Gênes (Italie) et ancien professeur de nanotechnologie à l'Université de Bologne (Italie). Il est titulaire d'un doctorat en biochimie et de biophysique de l'Université de Padoue (Italie), une master en physique de l'Université de Gênes (Italie), et un diplôme en électronique de l'Institut National de Technologie à Albenga (Italie). Ses intérêts scientifiques sont sur les phénomènes électriques de films nano-bio-structuré, et comprennent CMOS conception de biopuces à base de protéines et de l'ADN. Le long de sa carrière, il a publié 7 livres, l'un comme auteur avec Springer sur les interfaces Bio/CMOS et, plus récemment, un manuel de bioélectronique avec La prestigieuse Cambridge University Press. Il a également publié plus de 250 articles scientifiques et est l'auteur de 13 brevets. Il est maintenant chef rédacteur du Journal IEEE Sensors; il est également fondateur et chef rédacteur du Journal BioNanoScience par Springer, et rédacteur adjoint de IEEE Transactions on Circuits and Biomedical Systems. Il est membre du IEEE Sensors Council et de son comité exécutif. Il était membre du Conseil des gouverneurs de la IEEE Circuits And Systems Society (CASS). Il a été nommé IEEE conférencier émérite pour les années 2017-2019 pour le Conseil IEEE Sensors, et de la société CASS pour les années 2013-2014. Son travail a reçu plusieurs reconnaissances internationales: plusieurs Top-25 Hottest-articles (2004, 2005, 2008, 2009, et deux fois en 2012) publiés dans des journaux internationales très fort impact telles que Biosensors and Bioelectronics, Sensors And Actuators B, IEEE Sensors, et Thin Solid Films; un Award à une conference de l'OTAN en 1996 pour la contribution originale à la physique de la conductivité à électron unique dans les nano-particules; six "Best Paper Awards" pour des articles présentés à la conférence IEEE Sensors Conference en 2019 (Montreal), IEEE NGCAS en 2017 (Genoa), MOBIHEALTH en 2016 (Milan), IEEE PRIME en 2015 (Glasgow), en 2010 (Berlin) et en 2009 (Cork), un prix de la meilleure affiche au rencontre annuel de Nanotera en 2011 (Berne), et un prix de la meilleure affiche au NanoEurope Symposium en 2009 (Rapperswil). De 1997 à 2000, il a été membre d'un comité international au ELETTRA Synchrotron à Trieste. De 2000 à 2003, il était responsable scientifique d'un Programme national de recherche (PNR) dans le dépôt de nanobiotechnologie. Il était un expert internationalement estimé du comité d'évaluation de l'Académie de Finlande dans un programme de recherche pour les années 2010-2013. Il a été le président général (General Chair) de la Conférence IEEE BioCAS 2014, le premier conférence internationale dans le domaine des circuits et des systèmes pour les applications biomédicales.
John McKinney
Professor John McKinney received his Ph.D. from The Rockefeller University (New York, NY) in 1994 for studies on cell cycle regulation in
Saccharomyces cerevisiae
in the laboratory of Fred Cross. From 1995 to 1998, he was a postdoctoral fellow in the laboratory of William Jacobs at the Albert Einstein College of Medicine (Bronx, NY), where he studied mechanisms of persistence in
Mycobacterium tuberculosis
. In 1999, he returned to Rockefeller University to establish his own laboratory as an Assistant (1999-2004) and then Associate (2004-2007) Professor. In July 2007, the lab relocated to the Global Health Institute in the School of Life Sciences at the École Polytechnique Fédérale de Lausanne (EPFL) in Switzerland, where McKinney is Professor and Head of the Laboratory of Microbiology and Microsystems (LMIC). Our research focuses on understanding the mechanistic basis of bacterial persistence in the context of host immunity and antimicrobial therapy, using
M. tuberculosis
as a "model" system.
Hilal Lashuel
2012-2013 Visiting Professor, Standford University. Stanford School of Medicine
2011- Associate Professor of Life Sciences-Brain Mind Institute-EPFL
Dir. Laboratory of Chemical Biology of Neurodegeneration
2005-2011 Assistant Professor of Life Sciences-Brain Mind Institute-EPFL
Dir. Laboratory of Molecular Neurobiology and Neuroproteomics
2005-2008 Director- EPFL Proteomic Core Facility
2002-2004 Instructor of Neurology- Harvard Medical School and Brigham and Women's
Hospital
2001-2002 Sabbatical Fellow- Laboratory for Drug Discovery in Neurodegeneration
Harvard Medical School,
2001-2002 Post-doctoral Fellow- Center for Neurologic Diseases
Harvard Medical School and Brigham and Women's Hospital
Advisor- Prof. Peter T. Lansbury
2000-2001 Research Scientist, The Picower Institute for Medical Research, Great Neck
New York
1994-2000 PhD Student; Texas A&M University and the Scripps Research Institute
Advisor- Prof. Jeffery W. Kelly
1990-1994 B.S. City University of New York, Brooklyn College
Dr. Hilal A. Lashuel received his B.Sc. degree in chemistry from the City University of New York in 1994 and completed his doctoral studies at Texas A&M University and the Scripps Research Institute in 2000. After obtaining his doctoral degree, he became a research fellow at the Picower Institute for Medical Research in Long Island New York. In 2001, he moved to Harvard Medical School and the Brigham and Women's Hospital as a research fellow in the Center for Neurologic Diseases and was later promoted to an instructor in neurology at Harvard Medical School. During his tenure (2001-2004) at Harvard Medical School his work focused on understanding the mechanisms of protein misfolding and fibrillogenesis and the role of these processes in the pathogenesis of Parkinson's and Alzheimer's disease. In 2005 Dr. Lashuel moved Switzerland to join the Brain Mind Institute at the Swiss Federal Institute of Technology Lausanne as a tenure-track assistant professor in neurosciences. Currently, Dr. Lashuel is an associate professor of life sciences and the director of the laboratory of molecular and chemical biology of neurodegeneration. (http://lashuel-lab.epfl.ch/).
Research efforts in the Lashuels laboratory focus on understanding the molecular mechanisms of neurodegeneration and developing novel strategies to diagnose and treat neurodegenerative diseases such as Alzheimers and Parkinsons disease. Research in the Lashuel lab is funded by several international funding agencies and foundations, including the Swiss National Science Foundation, European FP7 program (Marie Curie and ERC grants), Human Science Frontiers, Strauss Foundation, Cure the Huntingtons disease foundation and Michael J Fox foundation and is supported by collaborations with pharmaceutical and biotech companies (http://lashuel-lab.epfl.ch/page-50538-en.html), Nestle, Merck-Serono, AC Immune and Johnson and Johnson.
Dr. Lashuels research has resulted in the characterization of novel quaternary structure intermediates on the amyloid pathway, identification of potential therapeutic targets, and new hypotheses concerning the mechanisms of pathogenesis in Alzheimers disease, Parkinsons disease and related disorders. Dr. Lashuel scientific contribution to this field includes i) more than100 publications in major peer reviewed journals including Nature journals, Cell, PNAS, JBC, J. Neuroscience JACS, and Angewandtie Chemie; ii) three patents on novel strategies for preventing protein aggregation and treating autoimmune and inflammatory diseases; iii) more than 150 invited lectures since 2002 and more than 5500 citations (7800 citation-Google Scholar) since 1996. Dr. Lashuel has received several pre-doctoral and post-doctoral awards and fellowships and was the recipient of two prestigious awards given to young investigators; Human Science Frontiers young investigator research award and the European Research Council (ERC) starting independent researcher grant and the ERC proof of concept award (2013) These awards provide more than $2.5 Million to Dr. Lashuel to translate some of his ideas and projects into novel strategies for diagnosing and treating neurodegenerative diseases such as Alzheimers and Parkinsons disease. Dr. Lashuel has chaired and co-organized several international conferences and serves as an academic editor for PLoS ONE, an associate editor for frontiers of molecular neuroscience, member of the Editorial advisory board of ChemBioChem and ad hoc reviewer for several international scientific journals and funding agencies.
Pierre Vogel
Professional positions:
P. Vogel was born in Cully (Switzerland) Oct. 23, 1944. In 1969, he did his Ph.D Award under supervision of Prof. H. Prinzbach at the Institute of Organic Chemistry, University of Lausanne. After finishing his Ph.D in 1969, he did post-doctoral research at Yale University, New Haven, Connecticut, USA with Prof. Martin Saunders; research associate with Prof. J. A. Berson, K. A. Wiberg and P.v.R. Schleyer (Princeton Universtiy). From 1971 he worked as a Research chemist at Syntex S.A., in Mexico with Prof. P.Crabbé before he returned to the University of Lausanne in 1972. As of 1977 he became Professor of organic chemistry at the University of Lausanne. In 1991 he was Vice-Chairman of the Institute of organic Chemistry, University of Lausanne until 2001. Then he was Part-time grad.school teacher at the Universitites of Rouen and Caen from 1991 to 1993 and Part-time professor at Ecole Polytechnique de Palaiseau from 1993-2000. From 2000-2001 he was reviewer of the "Institut Universitaire de France" and as of 2001 Professor of organic chemistry at the EPFL.
Degrees and distincions
1969 Ph.D, University of Lausanne
1976 Swiss Chemical Society Award, Werner Medal
1973-now Member of the Swiss Chemical Society, of the American Chemical
Society and "Société Française de Chimie"
1984-1989 IOCD adviser
1988-1989 Associate Professor of Organic Chemistry at Ecole Normale
Supérieure, Paris
1989-2000 Member of the Swiss National Council of Research
1991-1992 Associate Professor of Organic Chemistry, University of Paris VI
1992 Pacific Coast Lecturer (USA)
1992-1993 Associate Professor at the Université de Montpellier, France
1993 Associate Professor, Université Paris Sud, Orsay
1993-1997 Swiss co-ordinator of the European COST D2 research program
1994 (spring) Associate Professor, ESPCI, Paris
1997 President of the european COST D2 management committee
1999 Coordinator of the european COSRD13
2001-now Member of the "Conseil Scientifique du Département des Sciences
Chimiques", CNRS
2002-2003 Novartis Lectureship
2004-2005 Boehringer INgelheim Distinguished Lecturer