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A method is described to determine the effect on the ECG of a reduced propagation velocity within an ischemic zone. The method was designed to change the activation sequence throughout the ventricles interactively, i.e. with a response time in the order of ...
The identification of cellular pathways capable of limiting ischemia/reperfusion (I/R) injury remains a frontier in medicine, and its clinical relevance is urgent. Histidine triad nucleotide binding protein 1 (HINT1) is a tumor suppressor that influences a ...
To evaluate the haemodynamic changes induced by flow diversion treatment in cerebral aneurysms, resulting in thrombosis or persisting aneurysm patency over time. Eight patients with aneurysms at the para-ophthalmic segment of the internal carotid artery we ...
The intestine is today still an organ whose mechanisms of functions are not fully understood. The diffculty in its understanding comes from the fact that it is regulated by a complex network of signals of different natures. Granting that a multitude of exp ...
EPFL2005
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Peripheral arterial disease (PAD) is a common disease with increasing prevalence, presenting with impaired walking ability affecting patient's quality of life. PAD epidemiology is known, however, mechanisms underlying functional muscle impairment remain un ...
The aim of this study was to test the sustained release of insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF) using an injectable supramolecular hydrogel based on ureido-pyrimidinone (UPy) moieties in order to recruit and activate endo ...
A third of patients with critical limb ischemia (CLI) will eventually require limb amputation. Therapeutic neovascularization using unselected mononuclear cells to salvage ischemic limbs has produced modest results. The TIE2-expressing monocytes/macrophage ...
Background and Purpose—Despite the improving imaging techniques, it remains challenging to predict the outcome early after transient cerebral ischemia. The aim of this study was thus to identify early metabolic biomarkers for outcome prediction. Methods—We ...
BACKGROUND & AIMS: The WNT-adenomatous polyposis coli system controls cell fate in the intestinal epithelium, where compartment-specific genes tightly regulate proliferation, migration, and differentiation. Nuclear receptors are transcription factors funct ...
This study was performed to investigate the role of chronic pretreatment with angiotensin II type 1 receptor antagonists (ARB) and angiotensin converting enzyme inhibitors (ACE-I) in myocardial infarction (MI) and ischemic preconditioning (iPC). Little is ...
