Publications associées à MyoD

Chromatin Fiber Invasion and Nucleosome Displacement by the Rap1 Transcription Factor

Rudolf Hovius, Beat Fierz, Iuliia Boichenko, Maxime Nicolas Mivelaz, Anne-Marinette Thi Phuong Hanh Cao

Pioneer transcription factors (pTFs) bind to target sites within compact chromatin, initiating chromatin remodeling and controlling the recruitment of downstream factors. The mechanisms by which pTFs overcome the chromatin barrier are not well understood. ...

2019

Endogenous fluctuations of OCT 4 and SOX 2 bias pluripotent cell fate decisions

David Michael Suter, Cédric Deluz, Torgil Elias Friman, Andrea Brigitta Alber, Subashika Govindan, Daniel Strebinger

SOX2 and OCT4 are pioneer transcription factors playing a key role in embryonic stem (ES) cell self‐renewal and differentiation. How temporal fluctuations in their expression levels bias lineage commitment is unknown. Here, we generated knock‐in reporter f ...

2019

KAP1 facilitates reinstatement of heterochromatin after DNA replication

Didier Trono, Priscilla Turelli, Julien Léonard Duc, Sandra Eloise Kjeldsen, Annamaria Kauzlaric, Andrea Coluccio, Julien Paul André Pontis, Suk Min Jang, Benjamin Rauwel, Geneviève Almouzni

During cell division, maintenance of chromatin features from the parental genome requires their proper establishment on its newly synthetized copy. The loss of epigenetic marks within heterochromatin, typically enriched in repetitive elements, endangers ge ...

2018

Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells

Didier Trono, Priscilla Turelli, Julien Léonard Duc, Sandra Eloise Kjeldsen, Gabriela Ecco, Andrea Coluccio

Abstract BACKGROUND: The KZFP/KAP1 (KRAB zinc finger proteins/KRAB-associated protein 1) system plays a central role in repressing transposable elements (TEs) and maintaining parent-of-origin DNA methylation at imprinting control regions (ICRs) during the ...

2018

Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes

Andrea Ferrari, Michela Casanova

Embryonal Rhabdomyosarcoma (ERMS) and Undifferentiated Pleomorphic Sarcoma (UPS) are distinct sarcoma subtypes. Here we investigate the relevance of the satellite cell (SC) niche in sarcoma development by using Hepatocyte Growth Factor (HGF) to perturb the ...

Elife Sciences Publications Ltd2016

The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma

Michel Aguet, Ivan Stamenkovic, Tanja Petricevic

Expression of the SS18/SYT-SSX fusion protein is believed to underlie the pathogenesis of synovial sarcoma (SS). Recent evidence suggests that deregulation of the Wnt pathway may play an important role in SS but the mechanisms whereby SS18-SSX might affect ...

Nature Publishing Group2016

A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation

Didier Trono, Evaristo Jose Planet Letschert, Marco Cassano, Suk Min Jang

The transcriptional activator MyoD serves as a master controller of myogenesis. Often in partnership with Mef2 (myocyte enhancer factor 2), MyoD binds to the promoters of hundreds of muscle genes in proliferating myoblasts yet activates these targets only ...

Cold Spring Harbor Lab Press, Publications Dept2015

Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk

Cathrin Brisken, Jacques Rougemont, Ayyakkannu Ayyanan, Marian Caikovski, Renuga Devi Rajaram, Duje Buric

Ovarian hormones increase breast cancer risk by poorly understood mechanisms. We assess the role of progesterone on global stem cell function by serially transplanting mouse mammary epithelia. Progesterone receptor (PR) deletion severely reduces the regene ...

Wiley-Blackwell2015

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MyoD

Chromatin Fiber Invasion and Nucleosome Displacement by the Rap1 Transcription Factor

Endogenous fluctuations of OCT 4 and SOX 2 bias pluripotent cell fate decisions

KAP1 facilitates reinstatement of heterochromatin after DNA replication

Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells

Genomic targets and molecular partners of the chromatin regulator KAP1

Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes

The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma

A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation

Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells

Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk

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Chattez avec Graph Search

Chromatin Fiber Invasion and Nucleosome Displacement by the Rap1 Transcription Factor

Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes

Genomic targets and molecular partners of the chromatin regulator KAP1

Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk

Endogenous fluctuations of OCT 4 and SOX 2 bias pluripotent cell fate decisions

KAP1 facilitates reinstatement of heterochromatin after DNA replication

Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells

The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma

A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation

Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells