Intraclass correlation | EPFL Graph Search

In statistics, the intraclass correlation, or the intraclass correlation coefficient (ICC), is a descriptive statistic that can be used when quantitative measurements are made on units that are organized into groups. It describes how strongly units in the same group resemble each other. While it is viewed as a type of correlation, unlike most other correlation measures, it operates on data structured as groups rather than data structured as paired observations. The intraclass correlation is commonly used to quantify the degree to which individuals with a fixed degree of relatedness (e.g. full siblings) resemble each other in terms of a quantitative trait (see heritability). Another prominent application is the assessment of consistency or reproducibility of quantitative measurements made by different observers measuring the same quantity. Early ICC definition: unbiased but complex formula The earliest work on intraclass correlations focused on the case of paired mea

Predrilled locking compression plate is more accurate than tension band wiring in restoring articular geometry of the ulnar greater sigmoid notch after olecranon Chevron osteotomy

Alexandre Terrier, Frédéric Vauclair

Introduction: The olecranon Chevron osteotomy (OCO) is commonly used to approach complex intraarticular fractures of the distal humerus. Predrilled tension band wiring (TBW) has historically been used to fix OCO. However, clinical outcomes are burdened by secondary loss of reduction and up to 21.3% non-union rates. The biomechanical stability of anatomic locking compression plate (LCP) was reported to be superior to TBW in olecranon fracture fixation. We hypothesised that this implant may also be superior to TBW in the anatomic reconstruction of the articular surfaces of the ulnar greater sigmoid notch after OCO by predrilling the holes of the angular stable plate with the threaded drill guide prior to osteotomy. Materials and methods: Lateral standardised and calibrated radiographs of twenty synthetic ulnar bones were obtained using a custom-made holder prior to preparation by a senior orthopaedic trauma surgeon. Ten specimens were then predrilled using the threaded drill bit guide of an olecranon LCP, while the other ten samples were predrilled with two 1.6 mm Kirschner wires. A distal "V" OCO was performed using a 0.6 mm oscillating saw. After repositioning and fixation with the corresponding device, lateral radiographs were repeated. Two independent observers used the TraumaCad planning software to document the articular geometry of the ulnar greater sigmoid notch pre- and postoperatively. The diameter of the best-fitting circle (diameter), the distance between the tip of the coronoid and the olecranon processes (distance) and the maximum articular depth were measured. Results: With the TBW technique, after OCO and fixation, all three postoperative measurements were significantly (p = 0.13). Inter and intra-observer measurement reliability was strong to very strong (intraclass correlation coefficients >= 0.793) for all three variables. Conclusion: Our study reveals that the predrilled LCP technique is more accurate than the predrilled TBW in restoring the anatomic articular geometry of the ulnar greater sigmoid notch after OCO. (C) 2020 Elsevier Ltd. All rights reserved.

ELSEVIER SCI LTD2020

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

Alessandro Barducci, Paolo De Los Rios, Duccio Malinverni

Hsp70 participates in a broad spectrum of protein folding processes extending from nascent chain folding to protein disaggregation. This versatility in function is achieved through a diverse family of J-protein cochaperones that select substrates for Hsp70. Substrate selection is further tuned by transient complexation between different classes of J-proteins, which expands the range of protein aggregates targeted by metazoan Hsp70 for disaggregation. We assessed the prevalence and evolutionary conservation of J-protein complexation and cooperation in disaggregation. We find the emergence of a eukaryote-specific signature for interclass complexation of canonical J-proteins. Consistently, complexes exist in yeast and human cells, but not in bacteria, and correlate with cooperative action in disaggregation in vitro. Signature alterations exclude some J-proteins from networking, which ensures correct J-protein pairing, functional network integrity and J-protein specialization. This fundamental change in J-protein biology during the prokaryote-to-eukaryote transition allows for increased fine-tuning and broadening of Hsp70 function in eukaryotes.

Elife Sciences Publications Ltd2017

Balanced Distributed Coding of Omnidirectional Images

Pascal Frossard, Vijayaraghavan Thirumalai, Ivana Tosic

This paper presents a distributed coding scheme for the representation of 3D scenes captured by a network of omnidirectional cameras. We consider a scenario where images captured at different viewpoints are encoded independently, with a balanced rate distribution among the different cameras. The distributed coding is built on multiresolution representation and partitioning of the visual information in each camera. The encoder then transmits one partition after entropy coding, as well as the syndrome bits resulting from the channel encoding of the other partition. The joint decoder exploits the intra-view correlation by predicting the missing source information with help of the syndrome bits. At the same time, it exploits the inter-view correlation by using motion estimation between images from different cameras. Experiments demonstrate that the distributed coding solution performs better than a scheme where images are handled independently, while the coding rate advantageously stays balanced between encoders.

2008

Predrilled locking compression plate is more accurate than tension band wiring in restoring articular geometry of the ulnar greater sigmoid notch after olecranon Chevron osteotomy

Alexandre Terrier, Frédéric Vauclair

ELSEVIER SCI LTD2020