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Publications associées (91)

Persistent spatial clusters of high body mass index in a Swiss urban population as revealed by the 5-year GeoCoLaus longitudinal study

Stéphane Joost, Idris Guessous, Murielle Bochud, Joël Chételat, Fred Michel Paccaud

OBJECTIVE Body mass index (BMI) may cluster in space among adults and be spatially dependent. Whether and how BMI clusters evolve over time in a population is currently unknown. We aimed to determine the spatial dependence of BMI and its 5-year evolution i ...

Bmj Publishing Group2016

Hierarchical Fingertip Space: A Unified Framework for Grasp Planning and In-Hand Grasp Adaptation

Aude Billard, Miao Li

We present a unified framework for grasp planning and in-hand grasp adaptation using visual, tactile, and proprioceptive feedback. The main objective of the proposed framework is to enable fingertip grasping by addressing problems of changed weight of the ...

Institute of Electrical and Electronics Engineers2016

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

Johan Auwerx, Carlos Canto Alvarez, Joanna Ratajczak

NAD(+) is a vital redox cofactor and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Supplementation with NAD(+) precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide ribosi ...

Nature Publishing Group2016

Association of PCK1 with Body Mass Index and Other Metabolic Features in Patients With Psychotropic Treatments

Pierre Magistretti, Aurélie Delacrétaz

Weight gain is a major health problem among psychiatric populations. It implicates several receptors and hormones involved in energy balance and metabolism. Phosphoenolpyruvate carboxykinase 1 is a rate-controlling enzyme involved in gluconeogenesis, glyce ...

Lippincott, Williams & Wilkins2015

Potential Mechanisms Leading to Overuse Injuries of the Back in Alpine Ski Racing - A Descriptive Biomechanical Study

Benedikt Fasel

Background: Overuse injuries of the back are a common complaint among top athletes and of competitive alpine skiers in particular. However, there is limited understanding about the sport-specific causes of these injuries that is essential for their prevent ...

Sage Publications Inc2015

Matrix-Assisted Transplantation of Functional Beige Adipose Tissue

Riccardo Sinisi, Grigory Karateev

Novel, clinically relevant, approaches to shift energy balance are urgently needed to combat metabolic disorders such as obesity and diabetes. One promising approach has been the expansion of brown adipose tissues that express uncoupling protein (UCP) 1 an ...

American Diabetes Association2015

A patient-specific numerical musculoskeletal knee model

Adeliya Latypova

Total Knee Arthroplasty (TKA) is a well-accepted surgical treatment of severe cases of osteoarthritis. Surgery is associated with improved pain level, knee function and health-related quality of life. Despite advances in surgical techniques and implant des ...

EPFL2015

The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa

Pierre Magistretti, Kai Wang

Objective: Although low weight is a key factor contributing to the high mortality in anorexia nervosa (AN), it is unclear how AN patients sustain low weight compared with bulimia nervosa (BN) patients with similar psychopathology. Studies of genes involved ...

Elsevier2014

PPAR beta/delta activation of CD300a controls intestinal immunity

Johan Auwerx

Macrophages are important for maintaining intestinal immune homeostasis. Here, we show that PPAR beta/delta (peroxisome proliferator-activated receptor beta/delta) directly regulates CD300a in macrophages that express the immunoreceptor tyrosine based-inhi ...

Nature Publishing Group2014

Vitamin D and energy homeostasis-of mice and men

Johan Auwerx, Kristina Schoonjans, Alessia Perino

The vitamin D endocrine system has many extraskeletal targets, including adipose tissue. 1,25-Dihydroxyvitamin D-3, the active form of vitamin D, not only increases adipogenesis and the expression of typical adipocyte genes but also decreases the expressio ...

Nature Publishing Group2014

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