Concept

Hypoxanthine-guanine phosphoribosyltransférase

Publications associées (8)

Selectively permeable microcapsules

Microcapsules are appealing containers for delivering active ingredients, such as drugs and cosmetics, or conducting chemical and biological reactions on a small scale. To control the timing and location of release of these encapsulants, the shells of micr ...

EPFL2023

Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip

Maartje Martina Cornelia Bastings

Extracellular vesicles (EVs) derived from various stem cell sources induce cardioprotective effects during ischemia-reperfusion injury (IRI). These have been attributed mainly to the antiapoptotic, proangiogenic, microRNA (miRNA) cargo within the stem cell ...

AMER ASSOC ADVANCEMENT SCIENCE2020

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

Stewart Cole, John McKinney, Neeraj Dhar, Claudia Sala, Ruben Hartkoorn, Anthony Vocat, Andréanne Lupien, Raphael Christopher Sommer

VCC234718, a molecule with growth inhibitory activity against Mycobacterium tuberculosis (Mtb), was identified by phenotypic screening of a 15344-compound library. Sequencing of a VCC234718-resistant mutant identified a Y487C substitution in the inosine mo ...

Amer Chemical Soc2017

Design of computational retrobiosynthesis tools for the design of de novo synthetic pathways

Vassily Hatzimanikatis, Noushin Hadadi

Designing putative metabolic pathways is of great interest in synthetic biology. Retrobiosynthesis is a discipline that involves the design, evaluation, and optimization of de novo biosynthetic pathways for the production of high-value compounds and drugs ...

Elsevier Sci Ltd2015

A comprehensive model of purine uptake by the malaria parasite Plasmodium falciparum: identification of four purine transport activities in intraerythrocytic parasites

Plasmodium falciparum is incapable of de novo purine biosynthesis, and is absolutely dependent on transporters to salvage purines from the environment. Only one low-affinity adenosine transporter has been characterized to date. In the present study we repo ...

Portland Press2008

Preparation of UDP-galacturonic acid using UDP-sugar pyrophosphorylase

Nicolai Cramer

UDP-galacturonic acid, the activated form of galacturonic acid (GalUA), is synthesized both de novo and by salvage pathways. The UDP-GalUA pyrophosphorylase gene involved in the salvage pathway has not been identified. Here we show that UDP-sugar pyrophosp ...

Elsevier2006

Optimization of regulatory architectures in metabolic reaction networks

Vassily Hatzimanikatis

Successful biotechnol. applications, such as amino acid prodn., have demonstrated significant improvement in bioprocess performance by genetic modifications of metabolic control architectures and enzyme expression levels. However, the stoichiometric comple ...

1996

Tissue preference and differentiation of malignant rat x mouse hybrid cells in chimaeric mouse fetuses

Denis Duboule

Mouse teratocarcinoma cells (OTT6050) deficient for thymidine kinase were fused with rat hepatoma cells ( Fu5AH ) deficient for hypoxanthine phosphoribosyltransferase using inactivated Sendai virus. The hybrid cells were selected and cultured in the presen ...

1982

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