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Publications associées (130)

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Chromatin condensation plays an important role in the regulation of gene expression. Recently, it was shown that the transcriptional activation of Hoxd genes during vertebrate digit development involves modifications in 3D interactions within and around th ...

National Academy of Sciences2015

TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

Didier Trono, Priscilla Turelli, Adamantia Kapopoulou, Johan Jakobsson

TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): ...

Elsevier2015

Evolutionally dynamic control of LINE-1 elements in embryonic stem cells

Natali Pennese

Mobile elements are important evolutionary forces that challenge genomic integrity. Long interspersed element-1 (L1, also known as LINE-1) is the only autonomous transposon still active in the human genome. It displays an unusual pattern of evolution, with ...

EPFL2015

Enhancer loops appear stable during development and are associated with paused polymerase

Daniël Noordermeer

Developmental enhancers initiate transcription and are fundamental to our understanding of developmental networks, evolution and disease. Despite their importance, the properties governing enhancer-promoter interactions and their dynamics during embryogene ...

Nature Publishing Group2014

Spatial separation of Xist RNA and polycomb proteins revealed by superresolution microscopy

Marion Leleu

In female mammals, one of the two X chromosomes is transcriptionally silenced to equalize X-linked gene dosage relative to XY males, a process termed X chromosome inactivation. Mechanistically, this is thought to occur via directed recruitment of chromatin ...

2014

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The corrinoid cofactor is essential to organohalide respiration (OHR) as key element in virtually all reductive dehalogenases. Desulfitobacteria, and more particularly D. hafniense, represent a group of versatile OHR bacteria able to produce corrinoids de ...

2014

The evolution of lncRNA repertoires and expression patterns in tetrapods

Anamaria Necsulea, Magali Soumillon

Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but the absence of lncRNA annotations in non-model organisms has precluded comparative an ...

Nature Publishing Group2014

Evolutionally dynamic L1 regulation in embryonic stem cells

Didier Trono, Priscilla Turelli, Julien Léonard Duc, Marc Samuel Friedli, Adamantia Kapopoulou, Gabriela Ecco, Andrea Coluccio, Suk Min Jang

Cold Spring Harbor Lab Press, Publications Dept2014

Structure-Based Engineering of a Minimal Porin Reveals Loop-Independent Channel Closure

Hans Wolfgang Grosse

Porins, like outer membrane protein G (OmpG) of Escherichia coli, are ideal templates among ion channels for protein and chemical engineering because of their robustness and simple architecture. OmpG shows fast transitions between open and closed states, w ...

Amer Chemical Soc2014

Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

Didier Trono, Bart Deplancke, Sebastian Martin Waszak, Sunil Kumar Raghav, Petra Catalina Schwalie, Andrea Corsinotti, Gilles Udin

Adipose tissue is a key determinant of whole body metabolism and energy homeostasis. Unraveling the regulatory mechanisms underlying adipogenesis is therefore highly relevant from a biomedical perspective. Our current understanding of fat cell differentiat ...

Elife Sciences Publications Ltd2014

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