Publications associées à 23andMe

The genetic architecture of complex human traits at the dawn of genomic medicine

The focus of the work presented in this thesis is the exploration of the genetic architecture of complex human traits - at the dawn of genomic medicine. The underlying mechanisms explaining the enormously polygenic nature of most human complex traits are ...

EPFL2021

Cell-free gene-regulatory network engineering with synthetic transcription factors

Sebastian Maerkl, Zoe Newell Swank, Nadanai Laohakunakorn

Gene-regulatory networks are ubiquitous in nature and critical for bottom-up engineering of synthetic networks. Transcriptional repression is a fundamental function that can be tuned at the level of DNA, protein, and cooperative protein-protein interaction ...

2019

Privacy in the Genomic Era

Jean-Pierre Hubaux, Jacques Fellay, Erman Ayday

Genome sequencing technology has advanced at a rapid pace and it is now possible to generate highlydetailed genotypes inexpensively. The collection and analysis of such data has the potential to support various applications, including personalized medical ...

Assoc Computing Machinery2015

Reconciling Utility with Privacy in Genomics

Jean-Pierre Hubaux, Mathias Jacques Jean-Marc Humbert, Amalio Telenti, Erman Ayday

Direct-to-consumer genetic testing makes it possible for everyone to learn their genome sequences. In order to contribute to medical research, a growing number of people publish their genomic data on the Web, sometimes under their real identities. However, ...

2014

Reconciling Utility with Privacy in Genomics

Jean-Pierre Hubaux, Mathias Jacques Jean-Marc Humbert, Amalio Telenti, Erman Ayday

Direct-to-consumer genetic testing makes it possible for everyone to learn their genome sequences. In order to contribute to medical research, a growing number of people publish their genomic data on the Web, sometimes under their real identities. However, ...

2014

IROme, a New High-Throughput Molecular Tool for the Diagnosis of Inherited Retinal Dystrophies

Tatiana Favez, Alexandra Iouranova, Pascal Escher

The molecular diagnosis of retinal dystrophies is difficult because of the very important number of genes implicated and is rarely helped by genotype-phenotype correlations. This prompted us to develop IROme, a custom designed in solution-based targeted ex ...

Hindawi Publishing Corporation2013

Contribution of Genetic Background, Traditional Risk Factors, and HIV-Related Factors to Coronary Artery Disease Events in HIV-Positive Persons

Jacques Fellay, Amalio Telenti, Xuan Li

Background. Persons infected with human immunodeficiency virus (HIV) have increased rates of coronary artery disease (CAD). The relative contribution of genetic background, HIV-related factors, antiretroviral medications, and traditional risk factors to CA ...

Oxford University Press2013

Objectives, criteria and methods for using molecular genetic data in priority setting for conservation of animal genetic resources

The genetic diversity of the world's livestock populations is decreasing, both within and across breeds. A wide variety of factors has contributed to the loss, replacement or genetic dilution of many local breeds. Genetic variability within the more common ...

Wiley-Blackwell2010

A model-based optimization framework for the inference on gene regulatory networks from DNA array data

Vassily Hatzimanikatis, Eleftherios Papoutsakis

Identification of the regulatory structures in genetic networks and the formulation of mechanistic models in the form of wiring diagrams is one of the significant objectives of expression profiling using DNA microarray technologies and it requires the deve ...

2004

23andMe

The genetic architecture of complex human traits at the dawn of genomic medicine

Cell-free gene-regulatory network engineering with synthetic transcription factors

Privacy in the Genomic Era

Reconciling Utility with Privacy in Genomics

Reconciling Utility with Privacy in Genomics

IROme, a New High-Throughput Molecular Tool for the Diagnosis of Inherited Retinal Dystrophies

Contribution of Genetic Background, Traditional Risk Factors, and HIV-Related Factors to Coronary Artery Disease Events in HIV-Positive Persons

Objectives, criteria and methods for using molecular genetic data in priority setting for conservation of animal genetic resources

A model-based optimization framework for the inference on gene regulatory networks from DNA array data

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The genetic architecture of complex human traits at the dawn of genomic medicine

IROme, a New High-Throughput Molecular Tool for the Diagnosis of Inherited Retinal Dystrophies

Cell-free gene-regulatory network engineering with synthetic transcription factors

Reconciling Utility with Privacy in Genomics

Contribution of Genetic Background, Traditional Risk Factors, and HIV-Related Factors to Coronary Artery Disease Events in HIV-Positive Persons

Reconciling Utility with Privacy in Genomics

Objectives, criteria and methods for using molecular genetic data in priority setting for conservation of animal genetic resources

Privacy in the Genomic Era

A model-based optimization framework for the inference on gene regulatory networks from DNA array data