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Publications associées (129)

Antagonistic interactions among structured domains in the multivalent Bicc1-ANKS3-ANKS6 protein network govern phase transitioning of target mRNAs

Daniel Constam, Benjamin Marcel Daniel Rothé, Céline Gagnieux, Simon Fortier, Céline Emmanuelle Schmuziger

The growing number of diseases linked to aberrant phase transitioning of ribonucleoproteins highlights the need to uncover how the interplay between multivalent protein and RNA interactions is regulated. Cytoplasmic granules of the RNA binding protein Bica ...

CELL PRESS2023

Whole genome doubling promotes tumorigenesis through loss of chromatin segregation and compartment repositioning

Ruxandra-Andreea Lambuta

Whole genome doubling (WGD) events are drivers of genetic innovation across vertebrate evolution. While generally detrimental to mammalian organisms, WGDs are crucial in the development of various plants and fungi, as well as for the terminal differentiati ...

EPFL2023

Controlling the crystal structure of succinic acid via microfluidic spray-drying

Esther Amstad, Aysu Ceren Okur

Many properties of materials, including their dissolution kinetics, hardness, and optical appearance, depend on their structure. Unfortunately, it is often difficult to control the structure of low molecular weight organic compounds that have a high propen ...

ROYAL SOC CHEMISTRY2023

Unveiling facet-dependent degradation and facet engineering for stable perovskite solar cells

Felix Thomas Eickemeyer

A myriad of studies and strategies have already been devoted to improving the stability of perovskite films; however, the role of the different perovskite crystal facets in stability is still unknown. Here, we reveal the underlying mechanisms of facet-depe ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Exploring the mechanisms governing nuclear cGAS localization and activity

Marilena Wischnewski

Recognition of pathogen-derived molecules through germline-encoded receptors is a fundamental principle of innate immunity. Pattern recognition receptors detect specific intracellular danger signals to trigger potent immune responses. The DNA sensor cyclic ...

EPFL2022

Step Change Detection for Improved ROCOF Evaluation of Power System Waveforms

Mario Paolone, Asja Derviskadic, Guglielmo Frigo, Alexandra Cameron Karpilow

In the analysis of power grid waveforms, the presence of amplitude or phase steps can disrupt the estimation of frequency and rate-of-change-of-frequency (ROCOF). Standard methods based on phasor-models fail in the extraction of signal parameters during th ...

IEEE2022

Identification and characterization of proteins that protect human telomeres from fragility

Anna Christina Näger

Difficulties to replicate telomeres - the ends of our chromosomes - can cause telomere shortening andgenome instability. These difficulties are due to the repetitive DNA sequence and distinct structures at telomeresthat challenge the semi-conservative DNA ...

EPFL2022

Pilus production in Acinetobacter baumannii is growth phase dependent and essential for natural transformation

Melanie Blokesch, Nina Vesel

Acinetobacter baumannii is a severe threat to human health as a frequently multidrug-resistant hospital-acquired pathogen. Part of the danger from this bacterium comes from its genome plasticity and ability to evolve quickly by taking up and recombining ex ...

2021

Microstructure Selection in Laser Remelted Fe-C-Si Alloys

Wilfried Kurz, Philippe Gilgien

Laser surface remelting at various velocities has been employed to study the selection of microstructures of high-purity Fe-C-Si alloys containing nominally 3.2 to 4.2 wt.% C and 1 to 3 wt.% Si. The microstructure of the remelted region consisted of metast ...

WALTER DE GRUYTER GMBH2021

Challenging endings: How telomeres prevent fragility

Joachim Lingner

It has become apparent that difficulties to replicate telomeres concern not only the very ends of eukaryotic chromosomes. The challenges already start when the replication fork enters the telomeric repeats. The obstacles encountered consist mainly of nonca ...

WILEY2021

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