Publications associées (11)

In-vivo investigation of electrochemical behavior of Ti and CoCrMo alloy in human synovial fluids

Yueyue Bao

With the development of modern medical techniques, the application of orthopedic implants has been continually increasing in recent years. Passive materials, such as Ti and its alloys as well as CoCrMo alloys, are widely used in artificial joints due to th ...
EPFL2023

A Review on Finite Element Modeling and Simulation of the Anterior Cruciate Ligament Reconstruction

Dimitar Yuriev Stanev

The anterior cruciate ligament (ACL) constitutes one of the most important stabilizing tissues of the knee joint whose rapture is very prevalent. ACL reconstruction (ACLR) from a graft is a surgery which yields the best outcome. Taking into account the com ...
FRONTIERS MEDIA SA2020

Influence of Bovine Serum Albumin (BSA) on the Tribocorrosion Behaviour of a Low Carbon CoCrMo Alloy in Simulated Body Fluids

Stefano Mischler, Shoufan Cao, Choshun Yoneyama

Tribocorrosion, as the interaction between mechanical wear and electrochemical corrosion, has been found to be the main problem causing the failure and limiting the lifetime of metal-on-metal artificial hip joints. Better understanding of the tribocorrosio ...
2020

Tribocorrosion under fluid lubrication

Shoufan Cao

Wear is still the key problem causing the failure and limiting the lifetime of artificial hip joints, especially for the polymer acetabular cup in the metal-on-polymer and ceramic-on-polymer articulations. To reduce the wear, metal-on-metal articulation ha ...
EPFL2016

In vivo electrochemical corrosion study of a CoCrMo biomedical alloy in human synovial fluids

Stefano Mischler

The present study was initiated with the aim to assess the in vivo electrochemical corrosion behaviour of CoCrMo biomedical alloys in human synovial fluids in an attempt to identify possible patient or pathology specific effects. For this, electrochemical ...
Elsevier2015

Tribocorrosion of passive metals in the mixed lubrication regime: theoretical model and application to metal-on-metal artificial hip joints

Stefano Mischler, Shoufan Cao

Wear is a key problem limiting the lifetime and performance of total hip arthroplasty. The synovial fluid, acting as lubricant, can alleviate the wear of implants but also introduces corrosion. The interaction of mechanical wear and electrochemical corrosi ...
Elsevier2015

The In-Vivo Use of Superparamagnetic Iron Oxide Nanoparticles to Detect Inflammation Elicits a Cytokine Response but Does Not Aggravate Experimental Arthritis

Heinrich Hofmann, Lionel André Maurizi

Background Superparamagnetic Iron Oxide Nanoparticles (SPION) are used in diagnostic imaging of a variety of different diseases. For such in-vivo application, an additional coating with a polymer, for example polyvinyl alcohol (PVA), is needed to stabilize ...
Public Library of Science2015

Structure of viral membrane-penetrating machines by electron cryo-microscopy and tomography

Sergey Nazarov

My PhD thesis aims to obtain the structure of several bacteriophages, including so-called “jumbo” phages, using the electron cryo-microscopy (cryo-EM) and to study the structural transformation of these viruses as they attach and infect the host cell. We a ...
EPFL2015

Thrombin-sensitive dual fluorescence imaging and therapeutic agent for detection and treatment of synovial inflammation in murine rheumatoid arthritis

Hubert van den Bergh

We have developed a thrombin-sensitive polymeric photosensitizer prodrug (T-PS) to selectively image and eradicate inflammatory lesions in rheumatoid arthritis (RA). Thrombin is a serine protease up-regulated in synovial tissues of rheumatoid arthritis (RA ...
Elsevier2012

Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage

Dominique André Rothenfluh

Osteoarthritis (OA) is one of the most common causes of pain and disability. Currently, non-surgical treatment is limited to analgesic and anti-inflammatory drugs, which are not capable of either modifying the disease process or regenerate damaged parts in ...
EPFL2009

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