Publications associées à Cancer colorectal héréditaire sans polypose

HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer

Hierarchical organization of tissues relies on stem cells, which either self-renew or produce committed progenitors predestined for lineage differentiation. Here we identify HOXA5 as an important repressor of intestinal stem cell fate in vivo and identify ...

Elsevier2015

The consensus molecular subtypes of colorectal cancer

Douglas Hanahan, Krisztian Homicsko, Sarah Gerster, Paolo Angelino, Mauro Delorenzi, Anguraj Sadanandam, Xin Wang

Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC classifications and facilitate clinical translation, we formed an international c ...

Nature Publishing Group2015

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

Paul Joseph Dyson, Christian Hartinger

The clinical development of anticancer metallodrugs is often hindered by the elusive nature of their molecular targets. To identify the molecular targets of an antimetastatic ruthenium organometallic complex based on 1,3,5-triaza-7-phosphaadamantane (RAPTA ...

2015

CL9/9L-beta-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer

Michel Aguet, Patrick Rodriguez, Mauro Delorenzi, Pascale Anderle Pedone, Andreas Eduard Moor, Norbert Wiedemann, Sylvie André Baflast, Frédérique Baruthio

BCL9/9L proteins enhance the transcriptional output of the beta-catenin/TCF transcriptional complex and contribute critically to upholding the high WNT signaling level required for stemness maintenance in the intestinal epithelium. Here we show that a BCL9 ...

Elsevier Science Bv2015

Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Débora Bonvin, Edoardo Scherrer

Tumor vasculature is known to be poorly organized leading to increased leakage of molecules to the extravascular space. This process can potentially increase interstitial fluid pressure impairing intra-tumoral blood flow and oxygen supply, and can affect d ...

2015

Engineering opportunities in cancer immunotherapy

Melody Swartz, Laura Jeanbart

Immunotherapy has great potential to treat cancer and prevent future relapse by activating the immune system to recognize and kill cancer cells. A variety of strategies are continuing to evolve in the laboratory and in the clinic, including therapeutic non ...

Natl Acad Sciences2015

Metabolic expressivity of human genetic variants: NMR metabotyping of MEN1 pathogenic mutants

David Lyndon Emsley

Functional consequences of mutations in predisposition genes for familial cancer syndromes remain often elusive, especially when the corresponding gene products play pleiotropic functions and interact with numerous partners. Understanding the consequences ...

ELSEVIER SCIENCE BV2014

Reconciliation of classification systems defining molecular subtypes of colorectal cancer

Douglas Hanahan, Anguraj Sadanandam, Xin Wang

Recently we published two independent studies describing novel gene expression-based classifications of colorectal cancer (CRC). Notably, each study stratified CRC into a different number of subtypes: one reported 3 subtypes, whereas the second highlighted ...

Landes Bioscience2014

PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnt(high) Metastatic Colon Cancer Cells

Nadine Fournier, Mauro Delorenzi, Simone Ragusa, Stavros Milatos

The Wnt pathway is abnormally activated in the majority of colorectal cancers, and significant knowledge has been gained in understanding its role in tumor initiation. However, the mechanisms of metastatic outgrowth in colorectal cancer remain a major chal ...

Elsevier2014

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Cancer colorectal héréditaire sans polypose

HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer

The consensus molecular subtypes of colorectal cancer

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

CL9/9L-beta-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer

Nanosensors for early cancer detection and for therapeutic drug monitoring

Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy

Engineering opportunities in cancer immunotherapy

Metabolic expressivity of human genetic variants: NMR metabotyping of MEN1 pathogenic mutants

Reconciliation of classification systems defining molecular subtypes of colorectal cancer

PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnt(high) Metastatic Colon Cancer Cells

Graph Chatbot

Chattez avec Graph Search

HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer

The consensus molecular subtypes of colorectal cancer

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy

CL9/9L-beta-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer

Metabolic expressivity of human genetic variants: NMR metabotyping of MEN1 pathogenic mutants

Engineering opportunities in cancer immunotherapy

PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnt(high) Metastatic Colon Cancer Cells

Nanosensors for early cancer detection and for therapeutic drug monitoring

Reconciliation of classification systems defining molecular subtypes of colorectal cancer