Concept

Benzyle

Publications associées (35)

Kinetic and Mechanistic Investigations of the Oxidation of Tramadol by Ferrate and Ozone

The kinetics and oxidation products (OPs) of tramadol (TRA), an opioid, were investigated for its oxidation with ferrate (Fe(VI)) and ozone (O-3). The kinetics could be explained by the speciation of the tertiary amine moiety of TRA, with apparent second-o ...

2012

Synthesis of C-linked Disaccharides and Analogues as Biomimetics of the TF Epitope

Maria Kolympadi

Glycoproteins and glycolipids are major components of the outer surface of mammalian cells. Their carbohydrate moieties, which are directed into the outer environment, serve as ligands for receptor proteins, such as lectins, pathogen proteins and antibodie ...

EPFL2011

simple physical model for the simultaneous rationalisation of melting points and heat capacities of ionic liquids

Paul Joseph Dyson

The anal. of potential energy surfaces of ion pairs within the framework of an anharmonic oscillator model allows rationalization and prediction of m.ps. (Tmp) and heat capacities (Cp) of ionic liqs. (ILs) comprising di- and trialkylimidazolium or tetraalk ...

Royal Society of Chemistry2010

Stereoselective Reactions with Stabilized Carbocations

Fides Benfatti

Benzylic carbocations, which are easily generated in situ from alcohols or acetates by Brønsted or Lewis acids, undergo selective facial discrimination in diastereoselective reactions (see scheme; FG=functional group). The A values are responsible for the ...

Wiley-Blackwell2009

Palladium-Catalyzed Intramolecular C-Arylation of Benzylic Carbon: Synthesis of 3-Benzoxazolylisoindolinones by a Sequence of Ugi-4CR/Postfunctionalization

Jieping Zhu

Submitting Ugi-adduct to two consecutive metal-catalyzed intramol. reactions, namely copper-catalyzed O-arylation and palladium-catalyzed C-arylation of benzylic carbon developed in the course of this study, affords the benzoxazolylisoindolinones, e.g., I, ...

2008

Asymmetric Total Synthesis of (-)-Quinocarcin

Jieping Zhu

(-)-Quinocarcin (I) has been synthesized in a longest linear sequence of 22 steps from 3-hydroxybenzaldehyde in 16% overall yield. The Pictet-Spengler reaction of L-tert-butyl-2-bromo-5-hydroxy phenylalanate, synthesized according to Corey-Lygo's enantiose ...

2008

IBX-mediated oxidative Ugi-type multicomponent reactions: application to the N and C1 functionalization of tetrahydroisoquinoline

Jieping Zhu

An Ugi-type reaction of tetrahydroisoquinoline with an isocyanide and a carboxylic acid in the presence of iodoxybenzoic acid (IBX) afforded the 1,2-diacylated adduct in good to excellent yields. E.g., in the presence of IBX, reaction of 1,2,3,4-tetrahydro ...

2007

Intermediate and Process of Preparation of Ecteinascidin Such As Ecteinascidines-583, 597 Using Such Intermediate

Jieping Zhu, Jie Chen

The present invention concerns an intermediate of the following formula (I) in which R1 and R2 represent independently of each other a C1-C12 alkyl group, a (C1-C12 alkoxy)carbonyl group, optionally substituted by one, two or three halogen atom, a (C2-C12 ...

2007

Preparation of ecteinascidin alkaloids, such as ecteinascidins 583 and 597

Jieping Zhu

The present invention concerns an intermediate of the following formula I in which R 1 and R 2 represent independently of each other a C 1 -C 12 alkyl group, a (C 1 -C 12 alkoxy)carbonyl group, optionally substituted by one, two or three halogen atom, a (C ...

2007

Metalated 1-(p-methoxybenzyl)pyrazole: a structural chameleon

Levente Ondi

When treated with either butyllithium or lithium diisopropylamide, 1-(p-methoxybenzyl)pyrazole undergoes metalation at the exocyclic alpha-position but mutates to the 5-lithio species in the course of a few minutes or hours. Trapping the intermediates with ...

2006

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