Publication
The present invention concerns an intermediate of the following formula I in which R 1 and R 2 represent independently of each other a C 1 -C 12 alkyl group, a (C 1 -C 12 alkoxy)carbonyl group, optionally substituted by one, two or three halogen atom, a (C 2 -C 12 alkenyloxy) carbonyl group, an acyl group, a aryl(C 1 -C 12 )alkyl group, an arylalkoxy carbonyl group, a (C 1 -C 12 alkyl)sulfonyle group or an arylsulfonyl group and R 3 represents a O-protecting group. The present invention concerns also a process of preparation of the intermediate and its use for the preparation of Ecteinascidin 743 and Ecteinascidin-770.
Jeremy Luterbacher, Songlan Sun, Lorenz Perry Manker, Anastasiia Komarova
Jeremy Luterbacher, Songlan Sun, Stefania Bertella, Anastasiia Komarova
Kay Severin, Farzaneh Fadaei Tirani, Damien Wen Chen, Cesare Berton, Sylvain Alexandre Marie Sudan