Publications associées à Dual diagnosis

Ethological computational psychiatry: Challenges and opportunities

Studying the intricacies of individual subjects' moods and cognitive processing over extended periods of time presents a formidable challenge in medicine. While much of systems neuroscience appropriately focuses on the link between neural circuit functions ...

Current Biology Ltd2024

Neurobiological and metabolic basis of motivation and effort-based decision-making - A human 1H-MRS, fMRI and machine learning study

Arthur Barakat

Motivation is a multifaceted phenomenon that we explore within the framework of decision-making. Through this cognitive process, actions are directed towards specific goals by performing a trade-off between the cost and benefit of an action. The dorsomedia ...

EPFL2024

Cannabis use, cannabis use disorder and mental health disorders among pregnant and postpartum women in the US: A nationally representative study

Aaron Leor Sarvet

Background: Cannabis use and cannabis use disorder (CUD) are associated with mental health disorders, however the extent of this matter among pregnant and recently postpartum (e.g., new moms) women in the US is un-known. Associations between cannabis use, ...

2023

Repurposed drug combination via high-throughput screening and dual drug delivery system development for the treatment of retinoblastoma

Po-Jen Tseng

The goal of retinoblastoma (RB) treatment is to save the child's life, eyes and functional vision, with that order of priority. The management of RB is complex and involves strategically chosen methods of surgical enucleation, external beam radiotherapy, i ...

EPFL2022

Modeling and Inferring Attention between Humans or for Human-Robot Interactions

Rémy Alain Siegfried

More and more intelligent systems have to interact with humans. In order to communicate efficiently, these systems need to perceive and understand us. A key factor of communication is the people's visual focus of attention (VFOA), which is useful to estima ...

EPFL2021

Tapping into Multi-Faceted Human Behavior and Psychopathology Using fMRI Brain Dynamics

Dimitri Nestor Alice Van De Ville, Thomas William Arthur Bolton, Maria Giulia Preti, Elenor Morgenroth

Human behavior comprises many aspects that stand out by their dynamic nature. To quantify its neural underpinnings, time-resolved fMRI methods have blossomed over the past decade. In this review we conceptually organize a broad repertoire of dynamic analyt ...

2020

Pituitary dysmaturation affects psychopathology and neurodevelopment in 22q11.2 Deletion Syndrome

Dimitri Nestor Alice Van De Ville, Maria del Carmen Sandi Perez, Maude Schneider, Marie Schaer, Daniela Maria Zöller, Maëlle Chambaz

Background 22q11.2 Deletion Syndrome (22q11DS) confers strongly increased genetic risk for multiple psychiatric disorders. Similarly to the general population, rates of psychiatric comorbidity suggest that common disease mechanisms are shared across dimens ...

2020

Frontal cortical thickness correlates positively with impulsivity in early psychosis male patients

Alessandra Griffa, Kim Do

Aim Impulsive behaviours, which are frequent in young people suffering from psychosis have been linked to risky and violent behaviours and participate to the burden of psychotic illness. Given that morphological brain correlates of impulsivity in schizophr ...

WILEY2019

The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition

Giulia Palermo

The design of multitarget-directed ligands is a promising strategy for discovering innovative drugs. Here, we report a mechanistic study that clarifies key aspects of the dual inhibition of the fatty acid amide hydrolase (FAAH) and the cyclooxygenase (COX) ...

Wiley-V C H Verlag Gmbh2016

Impact of HSD11B1 polymorphisms on BMI and components of the metabolic syndrome in patients receiving psychotropic treatments

Pierre Magistretti, Murielle Bochud, Aurélie Delacrétaz

Background Metabolic syndrome (MetS) associated with psychiatric disorders and psychotropic treatments represents a major health issue. 11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) is an enzyme that catalyzes tissue regeneration of active cor ...

Lippincott Williams & Wilkins2015