Publications associées à Hypothermie thérapeutique

Multimodal transcriptomic atlases of mouse spinal cord injury

A spinal cord injury (SCI) triggers a cascade of molecular and cellular responses involving inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar surrounded by an astro ...

EPFL2024

Early Neuroprotective Effects of Bovine Lactoferrin Associated with Hypothermia after Neonatal Brain Hypoxia-Ischemia in Rats

Yohan Van de Looij

Neonatal hypoxic-ischemic (HI) encephalopathy (HIE) in term newborns is a leading cause of mortality and chronic disability. Hypothermia (HT) is the only clinically available therapeutic intervention; however, its neuroprotective effects are limited. Lacto ...

MDPI2023

Arrest Mechanisms of Buoyant Hydraulic Fractures

Brice Tanguy Alphonse Lecampion, Andreas Möri, Carlo Peruzzo, Dmitriy Garagash

Hydraulic fracturing (HF) treatments can form widespread fractures. Understanding their containment at depth is critical, given the positive buoyancy contrast between the fracturing fluid and the surrounding rock, promoting upward growth. We study arrest m ...

American Rock Mechanics Association (ARMA), OnePetro2023

Clinical detection of 'cold stress' is overlooked: an online survey of healthcare workers to explore the gap in neonatal thermal care in low-resource settings

Background Neonatal hypothermia has been widely regarded as a major contributory factor to neonatal mortality and morbidity in low-resource settings. The high prevalence of potentially preventable hypothermia today urges an investigation into why neonates ...

BMJ PUBLISHING GROUP2022

Clinical value of assessing motor performance in postacute stroke patients

Kamiar Aminian, Anisoara Ionescu, Fabien Massé

Background Rehabilitative treatment plans after stroke are based on clinical examinations of functional capacity and patient-reported outcomes. Objective information about daily life performance is usually not available, but it may improve therapy personal ...

BioMed Central2021

Deep Learning Building on Prior Ischemic Core Segmentation Improves Prediction of Infarction After Stroke

Dimitri Nestor Alice Van De Ville, Elisabeth Anne Dirren, Maria Giulia Preti, Guillaume Paul Olivier Leclerc

Introduction: Imaging studies are used to guide patient selection for acute stroke treatment. Perfusion CT (pCT) is widely used to identify the acute ischemic core and penumbra, but the prediction of the final infarct remains challenging. With the advent o ...

LIPPINCOTT WILLIAMS & WILKINS2021

Mild Neonatal Brain Hypoxia-Ischemia in Very Immature Rats Causes Long-Term Behavioral and Cerebellar Abnormalities at Adulthood

Yohan Van de Looij, Hongxia Lei

Systemic hypoxia-ischemia (HI) often occurs during preterm birth in human. HI induces injuries to hinder brain cells mainly in the ipsilateral forebrain structures. Such HI injuries may cause lifelong disturbances in the distant regions, such as the contra ...

2019

A Variable Stiffness Catheter Controlled with an External Magnetic Field

Dario Floreano, Alice Tonazzini

Remote magnetic navigation of catheters is a technique used to perform radiofrequency ablation of heart tissue in order to treat cardiac arrhythmias. The flexible magnetic catheters used in this context are in some cases not sufficiently dexterous to navig ...

IEEE2017

Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia

Yohan Van de Looij

Cerebral white matter injury is a leading cause of adverse neurodevelopmental outcome in prematurely born infants involving cognitive deficits in later life. Despite increasing knowledge about the pathophysiology of perinatal brain injury, therapeutic opti ...

Elsevier2016

Involvement of autophagy in hypoxic-excitotoxic neuronal death

Nikita Rudinskiy

Neuronal autophagy is increased in numerous excitotoxic conditions including neonatal cerebral hypoxia-ischemia (HI). However, the role of this HI-induced autophagy remains unclear. To clarify this role we established an in vitro model of excitotoxicity co ...

Landes Bioscience2014