Publications associées à Facteur anti-hémophilique B

De novo development of proteolytically resistant therapeutic peptides for oral administration

Christian Heinis, Luciano Andres Abriata, Florence Pojer, Xudong Kong, Vanessa Carle, Kaycie Marie Butler, Jun Moriya

The oral administration of peptide drugs is hampered by their metabolic instability and limited intestinal uptake. Here, we describe a method for the generation of small target-specific peptides (less than 1,600 Da in size) that resist gastrointestinal pro ...

2020

Tissue Factor-Independent Coagulation Correlates with Clinical Phenotype in Factor XI Deficiency and Replacement Therapy

Christian Heinis, Vanessa Carle, Alessandro Aliotta

Background In factor XI (FXI) deficiency, bleeding cannot be predicted by routine analyses. Since FXI is involved in tissue factor (TF)-independent propagation loop of coagulation, we hypothesized that investigating the spatiotemporal separated phases of c ...

GEORG THIEME VERLAG KG2020

Development of cyclic peptide inhibitors of coagulation factor XIa for safer anticoagulation

Vanessa Carle

Hemostasis is a complex physiological process responsible for the prevention of blood loss caused by vascular injury. The dysregulation of this delicate mechanism can lead to thromboembolic diseases, the leading cause of death worldwide. Anticoagulants are ...

EPFL2019

Patchy Amphiphilic Dendrimers Bind Adenovirus and Control Its Host Interactions and in Vivo Distribution

Francesco Stellacci, Weina Liu

The surface of proteins is heterogeneous with sophisticated but precise hydrophobic and hydrophilic patches, which is essential for their diverse biological functions. To emulate such distinct surface patterns on macromolecules, we used rigid spherical syn ...

2019

Rebounds of deformed cavitation bubbles

Mohamed Farhat, Danail Obreschkow, Outi Supponen

Presented here are experiments clarifying how the deformation of cavitation bubbles affects their rebound. Rebound bubbles carry the remaining energy of a bubble following its initial collapse, which dissipates energy mainly through shock waves, jets, and ...

AMER PHYSICAL SOC2018

Effect of treatment on the microstructural characteristics of bio-improved sand

Lyesse Laloui, Dimitrios Terzis

Bio-chemical processes have recently become the core of several studies in the geoengineering field, where the emphasis is placed on new and emerging applications. Microbially Induced Calcite Precipitation has been introduced as an alternative cementation ...

IOS Press, 20152015

Biologically active secondary metabolites from cyanobacteria

Cyril Portmann

For millennia, nature was the only source of medicine for mankind. Even today natural products represent a large proportion of the drugs in use. In some areas, like cancer or infectious diseases, about 50 % of the compounds used are of natural origin. Cyan ...

EPFL2010

Coagulants of Moringa Oleifera Lam. seeds : purification & characterisation

Water has been declared a human right by the United Nations, thus urging countries who have ratified the International Covenant on Economic, Social and Cultural Rights to ensure supply with drinking water for their populations1. However, supply of drinking ...

EPFL2005

Organ distribution of gene expression after intravenous infusion of targeted and untargeted lentiviral vectors

Didier Trono, Romain Zufferey

Lentiviral vectors represent an attractive technology platform from which to develop a targetable injectable gene delivery system for transduction of specific cell populations in vivo, irrespective of their cell cycle status. Targeted HIV-1-based lentivira ...

2001