Concept

Degenerative disc disease

Publications associées (35)

Multi-Scale Modeling Of Photopolymerization For Medical Hydrogel-Implant Design

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Salma Farahi, Azadeh Khoushabi

We report on the modeling of a photopolymerizable hydrogel and its application as a replacement of the interior of the intervertebral disc (so called Nucleus Pulposus). The hydrogel is initially injected in its liquid form and then photopolymerized via a s ...

Spie-Int Soc Optical Engineering2013

Damping properties of the nucleus pulposus

Dominique Pioletti, Arne Christian Vogel

Background: The nucleus pulposus is extremely deformable and it is not uncommon to observe strain amplitudes as large as 12.5% in physiological loading conditions. It has been shown that the nucleus pulposus contributes to the damping properties of the int ...

Elsevier2012

Temperature effect on connective tissue cells

Philippe Abdel Sayed, Salim Elias Darwiche

Intervertebral discs (IVD) are soft tissues that have viscoelastic behavior. Under cyclic loading, viscoelastic tissues dissipate the mechanical loading through the production of heat. In IVD, it is hypothesized that heat cannot be convected from the nucle ...

2012

High sensitivity recording of afferent nerve activity using ultra-compliant microchannel electrodes: an acute in vivo validation

Stéphanie Lacour, Ivan Rusev Minev

Neuroprostheses interfaced with transected peripheral nerves are technological routes to control robotic limbs as well as convey sensory feedback to patients suffering from traumatic neural injuries or degenerative diseases. To maximize the wealth of data ...

IOP Publishing2012

Biocomposite Hydrogels with Carboxymethylated, Nanofibrillated Cellulose Powder for Replacement of the Nucleus Pulposus

Pierre-Etienne Bourban, Ana Borges de Couraça, Fabien Duc

Biocomposite hydrogels with carboxymethylated, nanofibrillated cellulose (c-NFC) powder were prepared by UV polymerization of N-vinyl-2-pyrrolidone with Tween 20 trimethacrylate as a cross-linking agent for replacement of the native, human nucleus pulposus ...

2011

Thermomechanical Hysteresis of Biological and Synthetic Hydrogels

Arne Christian Vogel

The nucleus pulposus of the intervertebral disc is a gelatinous viscous hydrogel that has an essential role in the mechanics of the intervertebral disc joint. The viscoelastic properties of the nucleus pulposus significantly change in the course of time an ...

EPFL2011

Nanofibrillated cellulose composite hydrogel for the replacement of the nucleus pulposus

Dominique Pioletti, Pierre-Etienne Bourban, Ana Borges de Couraça, Fabien Duc

The swelling and compressive mechanical behavior as well as the morphology and biocompatibility of composite hydrogels based on Tween® 20 trimethacrylate (T3), N-vinyl-2-pyrrolidone (NVP) and nanofibrillated cellulose (NFC) were assessed in the present stu ...

2011

Heat transfer in Interverterbral Discs (IVDs)

Philippe Abdel Sayed

The Nucleus Pulposus (NP) is an avascular tissue that may be subject to temperature increase. Indeed, since the NP is not perfused by the cardio-vascular system, it implies that heat cannot be convected from it. The sources of heat could be either external ...

2011

Gel form of ECM-scaffold prepared from bovine Nucleus Pulposus.

Philippe Abdel Sayed, Alizée Jéléna Grimm

Decellularized tissues composed of extracellular matrix (ECM) and used as biologic scaffolds, have been shown to be useful for the repair of a variety of tissues. The clinical utility of such scaffolds for the tissue engineering of Nucleus Pulposus (NP) mi ...

2011

Soft-tissue viscoelasticity: extension to anisotropy and finite element implementation

Yannick Alain Frédéric Bastin

Biologic tissues such as the annulus fibrosus of the intervertebral disc present viscoelastic and anisotropic responses to mechanical loading. The objective of this semester project is to propose a method to implement routinely anisotropy-modelling in the ...

2011

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search