Concept

Degenerative disc disease

Publications associées (35)

Development of a medical instrument to induce and control hydrogel polymerization in-situ

Dominique Pioletti, Pierre-Etienne Bourban, Christophe Moser

Background - Nucleus pulposus degeneration is a very common musculo-skeletal pathology, which is in part responsible for low back pain, a pandemic medical problem. Artificial hydrogels are being investigated by research group around the world for the purpo ...

2010

Geometry- and load-specific optimization of the collagen network's fibre orientation in the lumbar spine's annulus fibrosus

Andreas Schmocker

In Europe, low back pain (LBP) affects the quality of life of up to 30% of the active population. Although the origin of LBP is not well identified and is probably not unique, epidemiological studies suggest that the severity of the disease is correlated w ...

2010

Composite Hydrogels for the Replacement of the Nucleus Pulposus

Ana Borges de Couraça

The intervertebral disc (IVD), which provides flexibility to the spine and facilitates damping and motion, is composed of two distinct structures: the annulus fibrosus (AF) and the nucleus pulposus (NP). The AF, which is fibrous and elastic, confines the N ...

EPFL2010

X-ray phase contrast imaging of the bone-cartilage interface

Synoyial joints articulate in a lubricating environment, the system providing for smooth articulation. The articular cartilage overlying the bone consists of a network of collagen fibres. This network is essential to cartilage integrity, suffering damage i ...

2010

Curing Kinetics and Mechanical Properties of a Composite Hydrogel for the Replacement of the Nucleus Pulposus

Dominique Pioletti, Pierre-Etienne Bourban, Ana Borges de Couraça

A polymer material system has been developed to propose an injectable, UV and in situ curable hydrogel with properties similar to the native nucleus pulposus of intervertebral disc. Neat hydrogels based on Tween® 20 trimethacrylates (T3) and N-vinyl-2-pyrr ...

Elsevier2010

Does viscoelasticity of a Hydrogel-cell construct affect ECM production?

Dominique Pioletti, Arne Christian Vogel, Line Aschwanden

Intervertebral disc (IVD) degeneration is one of the prevailing medical concern and actual health cost. Industries and academic institutions research for therapeutic solutions going from drugs to complete and partial arthroplasty devices as well as enginee ...

2009

Isolation and in vitro chondrogenic potential of human fetal spine cells

Dominique Pioletti, Corinne Scaletta, Sandra Jaccoud, Aurélie Quintin

Cell therapy for nucleus pulposus regeneration is an attractive treatment for early disc degeneration as shown by studies using autologous nucleus pulposus cells or stem cells. Another potential source of cells is fetal cells. We investigated the feasibili ...

2009

Does hydrogel-cell construct viscoelasticity affect ECM production?

Line Aschwanden

Low back pain is one of the most prevailing medical concerns and can often be associated with the degeneration of the intervertebral disc. This degeneration results in a loss of biological and mechanical properties, especially a loss of viscoelastic proper ...

2009

Soft-tissue viscoelasticity: extension to anisotropy and finite element implementation

Dominique Pioletti, Arne Christian Vogel

Physiological loading result to finite and finite rate of deformations of soft tissues such as ligament, tendons, and the annulus fibrosus of the intervertebral disc. Under these conditions, these soft tissues exhibit viscoelastic effects such as strain-st ...

2009

Design methodology and numerical optimization of ultrasonic transducers for spinal surgery

Daniel Porto

Nowadays, the general trend towards to minimally invasive interventions is present in all the medical domains. For the surgical intervertebral spinal disc cutting or removal domain, it is particularly a necessity because the manual methods currently employ ...

EPFL2009

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