Concept

Membrane nucléaire

Publications associées (126)

Drug loading of porous coating

Heinrich Hofmann, Laurent-Dominique Piveteau

Porous coating for the controlled release of drugs, said coating comprising a porous structure with pores adapted to act as reservoirs or as passages for a drug, in such a way that said drug can move from the external environment to/from or through said po ...

2006

Diffusion-Time Distribution Analysis Reveals Characteristic Ligand-Dependent Interaction Patterns of Nuclear Receptors in Living Cells

Horst Vogel, Horst Pick, Paulina Izewska, Hanna Jankevics

Nuclear receptors initiate transcription, interact with regulatory proteins, and are influenced by hormones, drugs, and pollutants. Herein, we discover ligand-specific mobility patterns of human estrogen receptor-a (ER) in living cells using diffusion-time ...

2005

Membrane permeabilization: a common mechanism in protein-misfolding diseases

Hilal Lashuel

Protein aggregation--and, more specifically, amyloid fibril formation--has been implicated as a primary cause of neurodegeneration in Alzheimer's disease, Parkinson's disease, and related disorders, but the mechanism by which this process triggers neuronal ...

2005

In-situ stabilization of membranes for improved large-area and high-density nanostencil lithography

Jürgen Brugger, Marc Antonius Friedrich van den Boogaart

Patterning of micro- and nanometer scale structures by means of nanostencils (shadow masks) is increasingly being used as a simple, clean and low-cost alternative to photolithography. It can be shown, that sub-100-nm scale features can be fabricated throug ...

2005

Oiling the key hole

Françoise Gisou van der Goot Grunberg

Many bacteria have been found to interact with specialized domains, rich in cholesterol and sphingolipids, of the host plasma membrane, termed lipid rafts. The mechanisms that underlie this interaction are starting to be unravelled. In this issue, Hayward ...

2005

Sir-mediated repression can occur independently of chromosomal and subnuclear contexts

Thierry Laroche

Epigenetic mechanisms silence the HM mating-type loci in budding yeast. These loci are tightly linked to telomeres, which are also repressed and held together in clusters at the nuclear periphery, much like mammalian heterochromatin. Yeast telomere anchori ...

2004

Reticulon 1-C/neuroendocrine-specific protein-C interacts with SNARE proteins

Liliane Glauser, Harald Hirling, Pascal Steiner, Juan-Carlos Sarria, Karina Kulangara

Reticulons are proteins of neuroendocrine cells localized primarily to the endoplasmic reticulum membrane. Despite their implication in cellular processes like apoptosis or axonal regeneration, their intracellular molecular function is still largely unknow ...

2004

Importin alpha associates with membranes and participates in nuclear envelope assembly in vitro

Importin alpha is well known as an adaptor that functions with Importin beta in the nuclear import of proteins containing specific nuclear localization signals (NLSs). We show here that either an excess or a lack of Importin alpha blocks nuclear envelope ( ...

Nature Publishing Group2004

Nuclear envelope: torn apart at mitosis

Pierre Gönczy

The findings of two recent studies suggest a novel mechanism for nuclear envelope breakdown in which cytoplasmic dynein anchored on the outside of the nucleus generates tension, thus triggering tearing of the nuclear envelope. ...

2002

Intracellular trafficking of yeast telomerase components

Joachim Lingner

Telomerase uses an internal RNA moiety as template for the synthesis of telomere repeats. In Saccharomyces cerevisiae, the telomerase holoenzyme contains the telomerase reverse transcriptase subunit Est2p, the telomerase RNA moiety TLC1, the telomerase ass ...

2002

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