Publications associées à Nicotinic agonist

GABA A receptors in the ventral tegmental area control the outcome of a social competition in rats

Maria del Carmen Sandi Perez, Michael van der Kooij, Ioannis Zalachoras

Social dominance can be attained through social competitions. Recent work in both humans and rodents has identified trait anxiety as a crucial predictor of social competitiveness. In addition, the anxiolytic GABAA positive modulator, diazepam, injected eit ...

2018

SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand

Kai Johnsson, Johannes Broichhagen, Helen Rebecca Ostlund Farrants

G protein-coupled receptors (GPCRs) mediate the transduction of extracellular signals into complex intracellular responses. Despite their ubiquitous roles in physiological processes and as drug targets for a wide range of disorders, the precise mechanisms ...

AMER CHEMICAL SOC2018

Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord motor disorders

Grégoire Courtine, Quentin Barraud, Pavel Musienko

The invention relates to the selective targeting of specific α2 adrenergic receptor subtypes for facilitating and also restoring standing and walking in a subject affected by spinal cord disorders, in particular spinal cord injury. In particular, the impro ...

2016

Endophenotypes of schizophrenia: electrophysiological correlates of schizotypy

Michael Herzog, Christine Mohr, Ophélie Gladys Favrod, Guillaume Sierro

Endophenotypes are of crucial interest for schizophrenia research linking genetic abnormalities to pathology. During the last NCCR period, we have characterized one endophenotype, based on visual backward masking (VBM) deficits, behaviourally, electrophysi ...

2015

Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides

Christian Heinis, Rudolf Hovius, Florence Pojer, Shiyu Chen, Ranganath Gopalakrishnan

The disulfide bonds that form between two cysteine residues are important in defining and rigidifying the structures of proteins and peptides. In polypeptides containing multiple cysteine residues, disulfide isomerization can lead to multiple products with ...

Nature Publishing Group2014

Visual backward masking deficits in schizotypy are observed in late but not early onset nicotine smokers

Michael Herzog, Christine Mohr, Guillaume Sierro, Géraldine Beaud

Visual backward masking (VBM) is a potential endophenotype for schizophrenia. Relative VBM deficits were also observed in high as compared to low scorers in one schizotypal subdimension (cognitive disorganisation, CogDis; Cappe et al., 2012). VBM deficits ...

2014

A Fluorescent Sensor for GABA and Synthetic GABA(B) Receptor Ligands

Kai Johnsson, Luc Reymond, Keitaro Umezawa, Anastasiya Masharina

While gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter, suitable tools to measure its concentration in living cells with high spatiotemporal resolution are missing. Herein, we describe the first ratiometric fluorescent sensor for GABA ...

American Chemical Society2012

Acetylcholine Receptor Organization in Membrane Domains in Muscle Cells: EVIDENCE FOR RAPSYN-INDEPENDENT AND RAPSYN-DEPENDENT MECHANISMS

Horst Vogel, Rudolf Hovius, Jean-Manuel Segura, Joachim Piguet, Christoph Schreiter

Nicotinic acetylcholine receptors (nAChR) in muscle fibers are densely packed in the postsynaptic region at the neuromuscular junction. Rapsyn plays a central role in directing and clustering nAChR during cellular differentiation and neuromuscular junction ...

American Society for Biochemistry and Molecular Biology2011

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Nicotinic agonist

GABA A receptors in the ventral tegmental area control the outcome of a social competition in rats

SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand

Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord motor disorders

Endophenotypes of schizophrenia: electrophysiological correlates of schizotypy

Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides

Visual backward masking deficits in schizotypy are observed in late but not early onset nicotine smokers

Probing Odorant-Mediated Receptor Activation

Genome-Wide Histone Acetylation Is Altered in a Transgenic Mouse Model of Huntington's Disease

A Fluorescent Sensor for GABA and Synthetic GABA(B) Receptor Ligands

Acetylcholine Receptor Organization in Membrane Domains in Muscle Cells: EVIDENCE FOR RAPSYN-INDEPENDENT AND RAPSYN-DEPENDENT MECHANISMS

Graph Chatbot

Chattez avec Graph Search

Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides

Visual backward masking deficits in schizotypy are observed in late but not early onset nicotine smokers

Endophenotypes of schizophrenia: electrophysiological correlates of schizotypy

GABA A receptors in the ventral tegmental area control the outcome of a social competition in rats

Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord motor disorders

SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand

Probing Odorant-Mediated Receptor Activation

A Fluorescent Sensor for GABA and Synthetic GABA(B) Receptor Ligands

Acetylcholine Receptor Organization in Membrane Domains in Muscle Cells: EVIDENCE FOR RAPSYN-INDEPENDENT AND RAPSYN-DEPENDENT MECHANISMS

Genome-Wide Histone Acetylation Is Altered in a Transgenic Mouse Model of Huntington's Disease