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Dernier ancêtre commun universel

Publications associées (35)

Beyond silence : a functional and evolutionary study of KRAB zinc finger proteins

Transposable elements (TEs) are genetic units capable of spreading within the genomes of their host. TEs contribute a readily recognizable 45% of the human DNA, reflecting in part their co-option for some as source of protein-coding sequences, for others a ...

EPFL2019

Assimilation, translocation, and utilization of carbon between photosynthetic symbiotic dinoflagellates and their planktic foraminifera host

Anders Meibom, Charlotte Madeleine Nicole Lekieffre, Emmanuelle Geslin

Some species of planktic foraminifera inhabiting oligotrophic surface water environments are in an obligate symbiotic relationship with dinoflagellate microalgae, which can assimilate carbon (C) through photosynthesis. However, the mechanism and dynamics o ...

2018

In silico tracing of the fate of single carbon atoms in different physiological states of E. coli

Jasmin Maria Hafner, Noushin Hadadi, Beatriz Lopes Pinto Basto Carreira

Many applications of systems biology such as the simulation of isotope labeling experiments and pathway inference in metabolic engineering rely on atom-level representation of metabolism. Because of its challenging complexity and the difficulty of obtainin ...

2018

Observation of Correlated Azimuthal Anisotropy Fourier Harmonics in $pp$ and $p+Pb$ Collisions at the LHC

Jian Wang, Matthias Finger, Lesya Shchutska, Qian Wang, Matthias Wolf, Varun Sharma, Konstantin Androsov, Jan Steggemann, Leonardo Cristella, Roberto Castello, Alessandro Degano, Xin Chen, Davide Di Croce, Mingkui Wang, Zhirui Xu, Chao Wang, João Miguel das Neves Duarte, Tagir Aushev, Tian Cheng, Yixing Chen, Werner Lustermann, Andromachi Tsirou, Alexis Kalogeropoulos, Andrea Rizzi, Ioannis Papadopoulos, Paolo Ronchese, Thomas Muller, Ho Ling Li, Giuseppe Codispoti, Hua Zhang, Siyuan Wang, Peter Hansen, Daniel Gonzalez, Tao Huang, David Vannerom, Michele Bianco, Ji Hyun Kim, Donghyun Kim, Dipanwita Dutta, Zheng Wang, Sanjeev Kumar, Wei Li, Yong Yang, Yi Wang, Ajay Kumar, Ashish Sharma, Georgios Anagnostou, Joao Varela, Csaba Hajdu, Muhammad Ahmad, Ekaterina Kuznetsova, Ioannis Evangelou, Matthias Weber, Muhammad Shoaib, Milos Dordevic, Vineet Kumar, Vladimir Petrov, Francesco Fiori, Quentin Python, Meng Xiao, Hao Liu, Viktor Khristenko, Marco Trovato, Gurpreet Singh, Fan Xia, Kai Yi, Bibhuprasad Mahakud, Lei Feng, Muhammad Waqas, Shuai Liu, Hui Wang, Seungkyu Ha, Davide Cieri, Maren Tabea Meinhard, Giorgia Rauco, Aram Avetisyan, Ali Harb, Benjamin William Allen, Pratyush Das

The azimuthal anisotropy Fourier coefficients (vn) in 8.16 TeV p+Pb data are extracted via long-range two-particle correlations as a function of the event multiplicity and compared to corresponding results in pp and PbPb collisions. Using a four-particle c ...

2018

Coral photosymbiosis: Linking phylogenetic identity to single cell metabolic activity in mixed symbiont populations

Anders Meibom, Isabelle Domart-Coulon, Maoz Fine, Béatrice Gaume

Tropical reef-building corals live in symbiosis with a wide range of micro-organisms, including unicellular Symbiodinium dinoflagellates also called zooxanthellae. These photosynthetic endosymbionts live inside the coral gastroderm cells. Although corals c ...

2017

KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks

Didier Trono, Michaël Imbeault, Pierre-Yves Joseph Laurent Helleboid

The human genome encodes some 350 Kruppel-associated box (KRAB) domain-containing zinc-finger proteins (KZFPs), the products of a rapidly evolving gene family that has been traced back to early tetrapods(1,2). The function of most KZFPs is unknown, but a f ...

Nature Publishing Group2017

Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control

Jacques Fellay, Amalio Telenti, Istvan Bartha

We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variat ...

Public Library of Science2017

Red squirrels in the British Isles are infected with leprosy bacilli

Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Jérémie Piton, Chloé Marie Loiseau

Leprosy, caused by infection with Mycobacterium leprae or the recently discovered Mycobacterium lepromatosis, was once endemic in humans in the British Isles. Red squirrels in Great Britain (Sciurus vulgaris) have increasingly been observed with leprosy-li ...

American Association for the Advancement of Science2016

Who Activates the Nucleophile in Ribozyme Catalysis? An Answer from the Splicing Mechanism of Group II Introns

Ursula Röthlisberger, Giulia Palermo, Lorenzo Casalino

Group II introns are Mg2+-dependent ribozymes that are considered to be the evolutionary ancestors of the eukaryotic spliceosome, thus representing an ideal model system to understand the mechanism of conversion of premature messenger RNA (mRNA) into matur ...

2016

Intermolecular Headgroup Interaction and Hydration as Driving Forces for Lipid Transmembrane Asymmetry

Sylvie Roke, Nikolay Smolentsev, Halil Ibrahim Okur, Cornelis Ulrich Lütgebaucks

Variations between the inner and outer leaflets of cell membranes are crucial for cell functioning and signaling, drug–membrane interactions, and the formation of lipid domains. Transmembrane asymmetry can in principle be comprised of an asymmetric charge ...

American Chemical Society2016

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