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Many biological processes depend on the sequential assembly of protein complexes. However, studying the kinetics of such processes by direct methods is often not feasible. As an important class of such protein complexes, pore-forming toxins start their jou ...
Nanoporous single-layer graphene (N-SLG) membranes, owing to their single-atom thinness, have the potential to exceed the permeance and selectivity limits of gas separation membranes. However, two key issues in the top-down N-SLG synthesis need to be addre ...
Biological filaments driven by molecular motors tend to experience tangential propulsive forces also known as active follower forces. When such a filament encounters an obstacle, it deforms, which reorients its follower forces and alters its entire motion. ...
The selectivity and speed of many biological transport processes(1) transpire from a 'reduction of dimensionality'(2) that confines diffusion to one or two dimensions instead of three(3). This behaviour remains highly sought after on polymeric surfaces(4) ...
Soluble karyopherins of the importin-beta (imp beta) family use RanGTP to transport cargos directionally through the nuclear pore complex (NPC). Whether imp beta or RanGTP regulate the permeability of the NPC itself has been unknown. In this study, we iden ...
The NUP214-ABL1 fusion kinase has recently been identified in 6% of patients with T-cell acute lymphoblastic leukemia. In contrast to the more common oncogenic ABL1 fusion BCR-ABL1, NUP214-ABL1 localizes to the nuclear pore complexes and has attenuated tra ...
Importin alpha is well known as an adaptor that functions with Importin beta in the nuclear import of proteins containing specific nuclear localization signals (NLSs). We show here that either an excess or a lack of Importin alpha blocks nuclear envelope ( ...
We have developed a novel technique for combined immunofluorescence/in situ hybridization on fixed budding yeast cells that maintains the three-dimensional structure of the nucleus as monitored by focal sections of cells labeled with fluorescent probes and ...
Telomerase uses an internal RNA moiety as template for the synthesis of telomere repeats. In Saccharomyces cerevisiae, the telomerase holoenzyme contains the telomerase reverse transcriptase subunit Est2p, the telomerase RNA moiety TLC1, the telomerase ass ...
The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. The MAC is formed by sequential assembly of soluble complement proteins C5b, C6, C7, C8 and C9, but little is known about th ...
