Publications associées à Selective androgen receptor modulator

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic steatosis and biliary cholestasis. In contrast to systemic therapy, bile a ...

Nature Publishing Group2015

Molecular basis for the regulation of the nuclear receptor LRH-1

Kristina Schoonjans, Matthias Alexander Sokrates Stein

Liver receptor homolog-1 (LRH-1) is a nuclear receptor (NR) with diverse functions in development, differentiation and metabolism and has been extensively studied in the enterohepatic system. While initially described as an orphan NR, recent studies sugges ...

Current Biology Ltd2015

The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-beta peptides

Patrick Fraering, Jianhua Liu, Jing Yu

Known gamma-secretase inhibitors or modulators display an undesirable pharmacokinetic profile and toxicity and have therefore not been successful in clinical trials for Alzheimer's disease (AD). So far, no compounds from natural products have been identifi ...

Nature Publishing Group2015

Intra- and interspecific social challenges modulate the levels of an androgen precursor in a seasonally territorial tropical damselfish

Katarina Damjanovic

Studies on different vertebrate groups have provided evidence that androgen levels in males increase after competitive social interactions during the breeding season, as postulated by the Challenge Hypothesis. However, social modulation of androgen levels ...

Academic Press Inc Elsevier Science2015

Bio-functionalization study of Memristive- Biosensors for Early Detection of Prostate Cancer

Giovanni De Micheli, Sandro Carrara, Ioulia Tzouvadaki

Silicon nanowires are reported for their application in bio sensing area and their potential in the detection of various biomolecules. In the present work, freestanding two-terminal Schottky-barrier silicon nanowire arrays exhibiting memristive behavior ar ...

2015

Potential of Cycloaddition Reactions To Generate Cytotoxic Metal Drugs In Vitro

Paul Joseph Dyson, Sviatlana Siankevich, Benjamin Samuel Murray, Stéphanie Crot

Severe general toxicity issues blight many chemotherapeutics utilized in the treatment of cancers, resulting in the need for more selective drugs able to exert their biological activity at only the required location(s). Toward this aim, we report the devel ...

Amer Chemical Soc2014

A KcsA/MloK1 Chimeric Ion Channel Has Lipid-dependent Ligand-binding Energetics

Henning Paul-Julius Stahlberg

Background: The mechanism of ligand gating in physiologically important cyclic nucleotide-modulated channels is unknown. Results: We constructed and purified a chimeric ion channel with activity modulated by cAMP and used it to measure ligand-binding energ ...

American Society for Biochemistry & Molecular Biology (ASBMB)2014

Ncor1 is a physiological modulator of muscle mass and oxidative function

Johan Auwerx, Laurent Mouchiroud, Hiroyasu Yamamoto

The present invention provides methods of increasing muscle mass and muscle miochodrial oxidative metabolism. Additionally, the invention provides treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic ...

2012

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Selective androgen receptor modulator

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Molecular basis for the regulation of the nuclear receptor LRH-1

The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-beta peptides

No Scope for Social Modulation of Steroid Levels in a Year-Round Territorial Damselfish

Intra- and interspecific social challenges modulate the levels of an androgen precursor in a seasonally territorial tropical damselfish

Bio-functionalization study of Memristive- Biosensors for Early Detection of Prostate Cancer

Potential of Cycloaddition Reactions To Generate Cytotoxic Metal Drugs In Vitro

A KcsA/MloK1 Chimeric Ion Channel Has Lipid-dependent Ligand-binding Energetics

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

Ncor1 is a physiological modulator of muscle mass and oxidative function

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Chattez avec Graph Search

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Ncor1 is a physiological modulator of muscle mass and oxidative function

Molecular basis for the regulation of the nuclear receptor LRH-1

Intra- and interspecific social challenges modulate the levels of an androgen precursor in a seasonally territorial tropical damselfish

Bio-functionalization study of Memristive- Biosensors for Early Detection of Prostate Cancer

A KcsA/MloK1 Chimeric Ion Channel Has Lipid-dependent Ligand-binding Energetics

No Scope for Social Modulation of Steroid Levels in a Year-Round Territorial Damselfish

Potential of Cycloaddition Reactions To Generate Cytotoxic Metal Drugs In Vitro

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-beta peptides