Concept

Récepteur ionotrope

Publications associées (236)

Anatomical, physiological and molecular properties of Martinotti cells in the somatosensory cortex of the juvenile rat

Henry Markram, Gilad Silberberg, Yi Wang

Whole-cell patch-clamp recordings followed by histochemical staining and single-cell RT-PCR were obtained from 180 Martinotti interneurones located in layers II to VI of the somatosensory cortex of Wistar rats (P13-P16) in order to examine their anatomical ...

2004

Plastic micropumps using ferrofluid and magnetic membrane actuation

Martinus Gijs, Christophe Yamahata

This paper presents a simple and low-cost prototyping technology for the realization of integrated micropumps in polymethylmethacrylate (PMMA). The three-dimensional (3D) micropumps consist of stacks of structured PMMA layers, which are either realised wit ...

IEEE2004

Analysis of low oxidation state transition metal clusters by laser desorption/ionization time-of-flight mass spectrometry

Paul Joseph Dyson

A variety of homonuclear and heteronuclear transition metal carbonyl clusters have been analyzed by ultraviolet laser desorption/ionization time-of-flight mass spectrometry. The spectra were recorded in negative and positive ion modes, using both linear an ...

2004

Thermodynamics of Binding of 2-Methoxy-3-isopropylpyrazine and 2-Methoxy-3-isobutylpyrazine to the Major Urinary Protein

Geoffrey Bodenhausen, Chiara Perazzolo

In the present study the authors examine the thermodn. of binding of two related pyrazine-derived ligands to the major urinary protein, MUP-I, using a combination of isothermal titrn. calorimetry (ITC), x-ray crystallog., and NMR backbone 15N and Me side-c ...

2004

Investigating cellular signalling reactions by micro- and nanotechnology

Horst Vogel

Classically, cellular signalling is investigated measuring different optical or elec. properties of either single cells or microliter vols. of suspensions of live cells. Here we show how ligand binding to cell surface receptors and subsequent signalling re ...

2004

Diastereoselective formation of metallamacrocyclic (arene)Ru-II and Cp*Rh-III complexes

Kay Severin

The reaction of (arene)RuCl2 (arene = cymene, 1,3,5-C6H3Me3) and Cp*RhCl2 half-sandwich complexes with tridentate heterocyclic ligands in the presence of base has been investigated. In all cases, the chloro-ligands were substituted to give metall ...

2004

Characterization of the Ligand-binding Site of the Serotonin 5-HT3 Receptor: The Role of Glutamate Residues 97, 224,and 235

Horst Vogel, Rudolf Hovius, Horst Pick, Christoph Schreiter, Matteo Costioli

Ligand-gated ion channels of the Cys loop family are receptors for small amine-contg. neurotransmitters. Charged amino acids are strongly conserved in the ligand-binding domain of these receptor proteins. To investigate the role of particular residues in l ...

2003

Highly electrically insulating tethered lipid bilayers for probing the function of Ion channel proteins

Horst Vogel, Samuel Terrettaz, Michael Mayer

A method is presented to form gold-electrode-tethered lipid bilayers with exceptionally high elec. resistances. Elec. impedance spectroscopy is used to monitor the bilayer incorporation of a ligand-gated ion channel protein and the modulation of its channe ...

2003

Multiaperture sample positioning and analysis system

Horst Vogel

Systems for positioning and/or analyzing samples such as cells, vesicles, cellular organelles, and fragments, derivs., and mixts. thereof, for elec. and/or optical anal., esp. relating to the presence and/or activity of ion channels. [on SciFinder (R)] ...

(Switz.).2003

Monitoring expression and clustering of the ionotropic 5HT3 receptor in plasma membranes of live biological cells

Horst Vogel, Rudolf Hovius, Horst Pick, Michael Mayer

The ionotropic 5HT3 receptor was expressed in transiently transfected mammalian cells, yielding an unprecedented high concn. of up to 12 million receptors per cell. Receptor traffic in the plasma membrane of live cells was obsd. continuously over 24 h by f ...

2003

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