Concept

Hyperkinesia

Publications associées (40)

Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates

Huntington's disease (HD) is a neurological disorder characterized by striatal degeneration, motor symptoms and complex neuropsychiatric alterations. There is currently no genetic model of HD in non-human primates (NHPs). In this study we investigated neur ...

2007

Quantification of tremor and bradykinesia in Parkinson’s disease using a novel ambulatory monitoring system

Kamiar Aminian, Arash Salarian

An ambulatory system for quantification of tremor and bradykinesia in patients with Parkinson's disease (PD) is presented. To record movements of the upper extremities, a sensing units which included miniature gyroscopes, has been fixed to each of the fore ...

2007

A Cross Validation Study of Deep Brain Stimulation Targeting: From Experts to Atlas-Based, Segmentation-Based and Automatic Registration Algorithms

Jean-Philippe Thiran, Meritxell Bach Cuadra, Reto Meuli, Olivier Cuisenaire, Francisco Javier Sanchez Castro

Validation of image registration algorithms is a difficult task and open-ended problem, usually application-dependent. In this paper we focus on deep brain stimulation (DBS) targeting for the treatment of movement disorders like Parkinson's disease and ess ...

2006

Plasticity of Spinal Cord Reflexes After a Complete Transection in Adult Rats: Relationship to Stepping Ability

Grégoire Courtine

Changes in epidurally induced (S1) spinal cord reflexes were studied as a function of the level of restoration of stepping ability after spinal cord transection (ST). Three types of responses were observed. The early response (ER) had a latency of 2.5 to 3 ...

2006

Ambulatory analysis of physical activities in Parkinson's disease using kinematics sensors

Kamiar Aminian, Arash Salarian

INTRODUCTION: Motor performance in Park-inson’s Disease (PD) patients is generally analyzed in laboratory. However, laboratory techniques do not allow estimating long-term ON/OFF fluctua-tion in PD patients. Here, we propose an ambula-tory system based on ...

2005

Unraveling a role for dopamine in Huntington's disease: the dual role of reactive oxygen species and D2 receptor stimulation

Huntington's disease (HD), an inherited neurodegenerative disorder, results from an abnormal polyglutamine extension in the N-terminal region of the huntingtin protein. This mutation leads to protein aggregation and neurotoxicity. Despite its widespread ex ...

2005

Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

Patrick Aebischer, Diana Zala

A lentiviral vector expressing a mutant huntingtin protein (htt171-82Q) was used to generate a chronic model of Huntington's disease (HD) in rat primary striatal cultures. In this model, the majority of neurons expressed the transgene so that Western blot ...

2005

Ambulatory gait analysis in Parkinson's Disease: Application of a novel method based on kinematics sensors

Kamiar Aminian, Catherine Dehollain, Arash Salarian

Summary: Using our ambulatory monitoring system, ASUR, 13 Parkinsonian patients were monitored for periods of up to 5 hours while they were free to perform activities at will. Every one hour patients did a UPDRS test as the clinical assessment. During the ...

ESMAC2004

Ambulatory measurement of gait parameters in Parkinson's disease: Effects of subthalamic stimulation

Kamiar Aminian, Catherine Dehollain, Arash Salarian

Introduction: In this study the effect of subthalamic nucleus neep brain Stimulation (STN-DBS) on the gait parameters of patients with Parkinson's disease (PD) was examined using an ambulatory gait analysis system based on miniature gyroscopes. The aim was ...

2003

Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration

Patrick Aebischer

The primate striatum contains tyrosine hydroxylase (TH)-immunoreactive (ir) neurons, the numbers of which are augmented after dopamine depletion. Glial cell line-derived neurotrophic factor (GDNF) strongly modulates the viability and phenotypic expression ...

2002

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