Concept

Maladie hémolytique du nouveau-né

Publications associées (33)

Electrical activity in rat cortico-limbic structures after single or repeated administration of lipopolysaccharide or staphylococcal enterotoxin B

Immune-to-brain communication is essential for an individual to aptly respond to challenging internal and external environments. However, the specificity by which the central nervous system detects or 'senses' peripheral immune challenges is still poorly u ...

2010

Analysis of the ITER ECH Upper Port Launcher remote maintenance using virtual reality

Timothy Goodman, René Chavan

All ITER sub-systems of remote handling (RH) classes 1 and 2 have to be remotely maintainable. The maintenance strategy for these components has to ensure system availability after failure or scheduled maintenance. This paper shows how virtual reality (VR) ...

Elsevier2009

Immunoisolated cell implants for intracerebral delivery of anti-Aß single chain Fv antibodies in the APP23 Alzheimer's mouse model

Osiris Marroquin Belaunzaran

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the elderly population. AD currently affects approximately 27 million people worldwide. A pathological hallmark of AD is the accumulation and deposition of the amyloid beta (Aβ) pe ...

EPFL2009

Wound healing gene-family expression differences between fetal and foreskin cells used for bioengineered skin substitutes

Dominique Pioletti, Corinne Scaletta, Nathalie Hirt-Burri

For tissue engineering, several cell types and tissues have been proposed as starting material. Allogenic skin products available for therapeutic usage are mostly developed with cell culture and with foreskin tissue of young individuals. Fetal skin cells o ...

2008

Preclinical comparison of mTHPC and verteporfin for intracavitary photodynamic therapy of malignant pleural mesothelioma

Georges Wagnières

Efficacy and tumour selectivity of photodynamic therapy with two clinically approved sensitizers (mTHPC, verteporfin) were assessed for focal intracavitary photodynamic therapy (PDT) in rodents with malignant pleural mesothelioma (MPM) at recommended drug- ...

Karger2006

Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates

Didier Trono

Generating lentiviral vectors pseudotyped with different viral glycoproteins (GPs) may modulate the physicochemical properties of the vectors, their interaction with the host immune system, and their host range. We have investigated the capacity of a panel ...

2002

CHO expression of a novel human recombinant IgG1 anti-RhD antibody isolated by phage display

Florian Maria Wurm, Martin Vogel

Replacement of the hyperimmune anti-Rhesus (Rh) D immunoglobulin, currently used to prevent haemolytic disease of the newborn, by fully recombinant human anti-RhD antibodies would solve the current logistic problems associated with supply and demand. The c ...

2000

The SPP biotech module 1: proteins for medical applications: a multidisciplinary effort for the development of a recombinant anti-RhD antibody preparation for the prevention of hemolytic disease of the newborn

Urs von Stockar, Florian Maria Wurm, Lucia Baldi Unser, Ian William Marison, Martin Jordan, Patrick Pugeaud, Philippe Pierre Girard, Lisa Hunt

A review with 0 refs. is presented regarding studies of a multidisciplinary team to establish the prophylactic principle and the manufg. process for anti-Rh D therapy based on recombinant antibody prepns. produced from Chinese hamster ovary cells. [on SciF ...

1999

Biotechnology in Lausanne. The Rh D project

Urs von Stockar, Florian Maria Wurm, Ian William Marison, Nicolas Mermod

A review is given with 2 refs. Hemolytic disease of the newborn is an often fatal condition of some newborn babies due to the immunogenicity of their Rh D pos. erythrocytes in the Rh D neg. mother. This condition can be prevented by injecting anti-Rh D ant ...

1999

The effect of cell line, transfection procedure and reactor conditions on the glycosylation of recombinant human anti-rhesus D IGG1

Urs von Stockar, Ian William Marison

An anti-Rhesus D antibody was produced in various cell-lines and cell-types which were either stable or transient transfected and grown under varying culture conditions. Glycosylation anal. of the IgG1 was carried out mainly by HPAEC methods. The antibody ...

1999

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