Concept

Histone

Publications associées (221)

Regulation of Steatohepatitis and PPARγ Signaling by Distinct AP-1 Dimers

Nonalcoholic fatty liver disease (NAFLD) affects up to 30% of the adult population in Western societies, yet the underlying molecular pathways remain poorly understood. Here, we identify the dimeric Activator Protein 1 as a regulator of NAFLD. Fos-related ...

Elsevier2014

Territorialism

This book is the result of the studio, Territorialism, held in fall 2012 and fall 2013 and taught by Paola Viganò. The studio examined the territorial scale and the form of the territory as a basis to understand the contemporary city and the important modi ...

Harvard University Press2014

Histone H3 K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes

Beat Fierz, Zhipeng Tang

Trimethylated histone H3 lysine 4 (H3K4) and H3K27 generally mark transcriptionally active and repressive chromatins, respectively. In most cell types, these two modifications are mutually exclusive and this segregation is crucial for the regulation of gen ...

American Society for Microbiology2013

The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription

Michel Aguet

Pygopus has been discovered as a fundamental Wnt signaling component in Drosophila. The mouse genome encodes two Pygopus homologs, Pygo1 and Pygo2. They serve as context-dependent beta-catenin coactivators, with Pygo2 playing the more important role. All P ...

Company Of Biologists Ltd2013

Structural Variation-Associated Expression Changes Are Paralleled by Chromatin Architecture Modifications

Jacques Rougemont, Marion Leleu, Nele Gheldof

Copy number variants (CNVs) influence the expression of genes that map not only within the rearrangement, but also to its flanks. To assess the possible mechanism(s) underlying this "neighboring effect", we compared intrachromosomal interactions and histon ...

Public Library of Science2013

Palmitoylation, pathogens and their host

Françoise Gisou van der Goot Grunberg, Sanja Blaskovic, Mathieu Blanc

S-Palmitoylation, the only reversible post-translational lipid modification, confers unique biochemical and functional properties to proteins. Although it has long been known that viral proteins are palmitoylated, recent studies reveal that this modificati ...

2013

Transgene- and locus-dependent imprinting reveals allele-specific chromosome conformations

Denis Duboule, Jozsef Zakany, Nicolas Lonfat

When positioned into the integrin alpha-6 gene, an Hoxd9lacZ reporter transgene displayed parental imprinting in mouse embryos. While the expression from the paternal allele was comparable with patterns seen for the same transgene when present at the neigh ...

National Academy of Sciences2013

Chromatin architectures and hox gene collinearity

Denis Duboule, Daniël Noordermeer

Ever since the observation that collinearity, that is, the sequential activity of Hox genes based on their relative positions within their gene clusters, is conserved throughout most of the animal kingdom, the question has been raised as to what are the un ...

Elsevier Academic Press Inc2013

The potential of HDAC inhibitors as cognitive enhancers

Johannes Gräff

Histone acetylation is a prominent epigenetic modification of the central nervous system that is unequivocally associated with an increase in the rate of gene transcription. Because gene transcription, in turn, plays an important role in long-lasting forms ...

2013

Histone acetylation: molecular mnemonics on the chromatin

Johannes Gräff

Long-lasting memories require specific gene expression programmes that are, in part, orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in cognitive processes, histone acetylation has spurred considerable interest. Whereas in ...

2013

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