Concept

CBL (gene)

Publications associées (5)

A Dimerized HMX1 Inhibits EPHA6/epha4b in Mouse and Zebrafish Retinas

HMX1 is a homeobox-containing transcription factor implicated in eye development and responsible for the oculo-auricular syndrome of Schorderet-Munier-Franceschetti. HMX1 is composed of two exons with three conserved domains in exon 2, a homeobox and two d ...

Public Library of Science2014

Nanoscale Imaging of Epidermal Growth Factor Receptor Clustering. Effects of Inhibitors

Dusan Vobornik

The development of some solid tumors is associated with overexpression of the epidermal growth factor receptor (EGFR) and often correlates with poor prognosis. Near field scanning optical microscopy, a technique with subdiffraction-limited optical resoluti ...

2010

Charting the molecular network of the drug target Bcr-Abl

Oliver Hantschel

The tyrosine kinase Bcr-Abl causes chronic myeloid leukemia and is the cognate target of tyrosine kinase inhibitors like imatinib. We have charted the protein-protein interaction network of Bcr-Abl by a 2-pronged approach. Using a monoclonal antibody we ha ...

2009

Structural basis for the autoinhibition of c-Abl tyrosine kinase

Oliver Hantschel

c-Abl is normally regulated by an autoinhibitory mechanism, the disruption of which leads to chronic myelogenous leukemia. The details of this mechanism have been elusive because c-Abl lacks a phosphotyrosine residue that triggers the assembly of the autoi ...

Elsevier2003

A myristoyl/phosphotyrosine switch regulates c-Abl

Oliver Hantschel

The c-Abl tyrosine kinase is inhibited by mechanisms that are poorly understood. Disruption of these mechanisms in the Bcr-Abl oncoprotein leads to several forms of human leukemia. We found that like Src kinases, c-Abl 1b is activated by phosphotyrosine li ...

Elsevier2003

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