Concept

Héroïne

Publications associées (8)

Introducing tolerance to foreign and partly foreign proteins by erythrocyte binding and artificial glycosylations

Over the last few years, protein drugs have steadily gained importance in the clinic. Compared to small molecule drugs, protein drugs are taken up by antigen presenting cells, which degrade the proteins into peptides that are then presented on major histoc ...

EPFL2018

Direct noninvasive estimation of myocardial tricarboxylic acid cycle flux in vivo using hyperpolarized 13C magnetic resonance

Rolf Gruetter, Hongxia Lei, Tian Cheng, Arnaud Comment, Josefina Adriana Maria Bastiaansen

BACKGROUND: The heart relies on continuous energy production and imbalances herein impair cardiac function directly. The tricarboxylic acid (TCA) cycle is the primary means of energy generation in the healthy myocardium, but direct noninvasive quantificati ...

Elsevier2015

A syndromic rash in patients attending methadone clinics in New South Wales

Karen Scrivener

We report an outbreak of a "rash" syndrome in patients attending methadone clinics in New South Wales. It presents with a pruritic, exanthematous or purpuric rash involving the trunk, limbs, palms and soles, which develops over a week and proceeds in most ...

2005

Immunoisolated xenogenic chromaffin cell therapy for chronic pain. Initial clinical experience

Patrick Aebischer, Julien Favre

BACKGROUND: Chromaffin cells from the adrenal gland secrete a mixture of compounds that have a strong analgesic effect, especially when administered intrathecally. Many studies in animal models have shown that discordant xenogeneic cell isolates, including ...

1996

Administration of leu-enkephalin impairs the acquisition of preference for ethanol

Maria del Carmen Sandi Perez

The effects of subcutaneous administration of leu-enkephalin (LEU-E) (10, 100 and 300 micrograms/kg) and LEU-E (100 micrograms/kg) plus naloxone (2.5 mg/kg) on ethanol preference and fluid intake have been investigated in rats. Under our procedural conditi ...

1990

Enkephalins interfere with early phases of voluntary ethanol drinking

Maria del Carmen Sandi Perez

The relationship between the opiate peptides Leu-enkephalin and [D-Ala2-Met5]enkephalinamide (DAME) and the initial expression and maintenance of ethanol preference was studied in male Wistar rats. Subcutaneous administration of both peptides prior to the ...

Elsevier1990

Beta-endorphin administration interferes with the acquisition and initial maintenance of ethanol preference in the rat

Maria del Carmen Sandi Perez

Attention has been focused on the possibility of an interaction between the endorphinergic system and ethanol intake. In the present study, the effects of subcutaneous (SC) administration of beta-endorphin (beta-E) (0.25, 1 and 5 micrograms/kg) and/or nalo ...

1989

Studies on the synthesis of morphine. VI. Recent progress on the biomimetic synthesis of morphine

Péter Kalman Péchy

Experiments to find a biomimetic route for synthesizing morphine are summarized. Systematic investigations on the phenolic oxidative coupling have been revised and evaluated. ...

1983

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