Concept

Métagénomique

Publications associées (203)

High-throughput approaches for the analysis of extrinsic regulators of stem cell fate

The complexity of stem cell niches poses a tremendous challenge to understanding mechanisms of extrinsic regulation of stem cell fate. In order to better understand niche signaling and its effect on stem cell fate choices, in vitro systems are being engine ...

2012

Computational analysis of protein-DNA interactions from ChIP-seq data

Felix Naef, Jacques Rougemont

Chromatin immunoprecipitation experiments followed by ultra-high-throughput sequencing (ChIP-seq) is becoming the method of choice to identify transcription factor binding sites in prokaryotes and eukaryotes in vivo. Here, we review the computational steps ...

2011

On the Relationship Between Protein-DNA Interactions and Circadian Gene Expression in Mouse Liver

Guillaume Rey

Virtually every cell in our body tracks daily time using an endogenous mechanism called the circadian clock, which has a period of about 24 hours. This timing system offers a selective advantage by enabling organisms to anticipate periodic changes in envir ...

EPFL2011

Microbial diversity of aerobic granular sludge: Is it different from activated sludge?

David Gregory Weissbrodt

This common presentation was given within the Aerobic Granular Sludge Workshop organized during the IWA Biofilm Conference 2011 (Shanghai, China). The aim was to bring the state-of-the-art knowledge on the microbial diversity present in aerobic granular sl ...

2011

Artificial niche microarrays for probing single stem cell fate in high throughput

Matthias Lütolf, Stefan Kobel, Samy Gobaa, Andrea Negro

To understand the regulatory role of niches in maintaining stem-cell fate, multifactorial in vitro models are required. These systems should enable analysis of biochemical and biophysical niche effectors in a combinatorial fashion and in the context of a p ...

Nature Publishing Group2011

PANDITplus: toward better integration of evolutionary view on molecular sequences with supplementary bioinformatics resources

Slavica Dimitrieva Janeva

Recent comparative genomic and other large-scale bioinformatics studies increasingly have been using gene annotations, functional classifications, and complimentary data from the emerging “-omics” disciplines. Indeed, such analyses have better chances to u ...

2010

Early stirrings of landscape genomics: Awaiting next-next generation sequencing platforms before take-off

Stéphane Joost

Landscape genomics is an emerging research field that bridges genetics and genomics to geo-environmental resources analysis. It aims to study genome/environment interaction to discover the genetic basis of adaptation by processing of many simultaneous DNA- ...

Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture2010

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2

Nouchine Hadjikhani, Fei Chen

Obesity has become a major worldwide challenge to public health, owing to an interaction between the Western 'obesogenic' environment and a strong genetic contribution(1). Recent extensive genome-wide association studies (GWASs) have identified numerous si ...

2010

Revealing strengths and weaknesses of methods for gene network inference

Dario Floreano, Claudio Mattiussi, Daniel Marbach, Thomas Schaffter

Numerous methods have been developed for inferring gene regulatory networks from expression data, however, both their absolute and comparative performance remain poorly understood. In this paper, we introduce a framework for critical performance assessment ...

2010

Performance and microbial community composition dynamics of aerobic granular sludge from sequencing batch bubble column reactors operated at 20, 30, and 35°

Christof Holliger, Julien Maillard, Pierre Rossi, Emmanuelle Rohrbach, Sirous Ebrahimi, Sébastien Gabus, Maryam Hosseini

Two bubble column sequencing batch reactors fed with an artificial wastewater were operated at 20, 30 and 35°C. In a first stage, stable granules were obtained at 20°C whereas fluffy structures were observed at 30°C. Molecular analysis revealed high abunda ...

Springer-Verlag2010

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