Concept

Hérédité non mendélienne

Publications associées (34)

The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects

Bruno Lemaitre, Maroun Bou Sleiman, Olivier Binggeli, Lise Bertin

Melanization contributes to arthropod-specific innate immunity through deposition of melanin at wound sites or around parasites, with concomitant release of microbicidal reactive oxygen species. Melanization requires sequential activation of proteolytic en ...

Elsevier2015

A Systems Approach to Identify Genetic and Environmental Regulators of Metabolism

Evan Graehl Williams

For more than a century, it has been recognized that our genetic inheritance and our environment interact to shape who we are and how we act (nature vs. nurture), and the study of genetics has allowed us to explain why traits can vary dramatically betwee ...

EPFL2014

Effects of ploidy and sex-locus genotype on gene expression patterns in the fire ant Solenopsis invicta

Chitsanu Khurewathanakul, Oksana Riba Grognuz, Laurent Keller

Males in many animal species differ greatly from females in morphology, physiology and behaviour. Ants, bees and wasps have a haplodiploid mechanism of sex determination whereby unfertilized eggs become males while fertilized eggs become females. However, ...

Royal Soc2014

Analysis of Stop-Gain and Frameshift Variants in Human Innate Immunity Genes

Jacques Fellay, Amalio Telenti, Istvan Bartha, Ioannis Xenarios

Loss-of-function variants in innate immunity genes are associated with Mendelian disorders in the form of primary immunodeficiencies. Recent resequencing projects report that stop-gains and frameshifts are collectively prevalent in humans and could be resp ...

Public Library Science2014

Salvage of the essential corrinoid cofactor in Dehalobacter restrictus

Christof Holliger, Julien Maillard, Yue Lu, Aamani Rupakula Boyanapalli, Sébastien Keller, Hauke Smidt

The corrinoid cofactor is essential for organohalide respiration (OHR), a bacterial metabolism assisting towards environmental depollution. Two different strategies for obtaining corrinoids, are used by OHR bacteria, either de novo biosynthesis or salvagin ...

2014

Transgene- and locus-dependent imprinting reveals allele-specific chromosome conformations

Denis Duboule, Jozsef Zakany, Nicolas Lonfat

When positioned into the integrin alpha-6 gene, an Hoxd9lacZ reporter transgene displayed parental imprinting in mouse embryos. While the expression from the paternal allele was comparable with patterns seen for the same transgene when present at the neigh ...

National Academy of Sciences2013

Non-genetic inheritance and the patterns of antagonistic coevolution

Marcel Salathé

Antagonistic species interactions can lead to coevolutionary genotype or phenotype frequency oscillations, with important implications for ecological and evolutionary processes. However, direct empirical evidence of such oscillations is rare. The rarity of ...

BioMed Central2012

Comprehensive analysis of Arabidopsis expression polymorphisms with simple inheritance

Darlene Goldstein

In Arabidopsis thaliana, gene expression level polymorphisms (ELPs) between natural accessions that exhibit simple, single locus inheritance are promising quantitative trait locus (QTL) candidates to explain phenotypic variability. It is assumed that such ...

2009

Uses of forward and reverse genetics in mice to study gene function

Johan Auwerx

As the focus of human genetics shifts from Mendelian traits to complex diseases, a sophisticated genetic tool kit—with space for genetics (classical, molecular, statistical, and quantitative), metabolics, proteomics, bioinformatics, and mathematics—is requ ...

Wiley2006

A single gene that promotes interaction of a phytopathogenic bacterium with its insect vector, Drosophila melanogaster

Bruno Lemaitre

Insects are major vectors of plant and animal disease, and bacterial phytopathogens are often disseminated by flies. We have previously reported that some isolates of the phytopathogenic bacterial species Erwinia carotovora infect Drosophila and activate a ...

Nature Publishing Group2003

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