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Publications associées (89)
Microtensile failure mechanisms in lamellar bone: Influence of fibrillar orientation, specimen size and hydration
Johann Michler, Daniele Casari, Tatiana Kochetkova
A mechanistic understanding of bone fracture is indispensable for developing improved fracture risk assessment in clinics. Since bone is a hierarchically structured material, gaining such knowledge requires analysis at multiple length scales. Here, the ten ...
ELSEVIER SCI LTD2021Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology
Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas, Fazil Emre Uslu
Mechanobiology explores how forces regulate cell behaviors and what molecular machinery are responsible for the sensing, transduction, and modulation of mechanical cues. To this end, probing of cells cultured on planar substrates has served as a primary ex ...
2021A Signal Peak Separation Index for axisymmetric B-tensor encoding
Jean-Philippe Thiran, Gabriel Girard, Marco Pizzolato, Jonathan Rafael Patino Lopez, Gaëtan Olivier D Rensonnet, Benoît Macq
Diffusion-weighted MRI (DW-MRI) has recently seen a rising interest in planar, spherical and general B-tensor encodings. Some of these sequences have aided traditional linear encoding in the estimation of white matter microstructural features, generally by ...
Springer2021Neurodegeneration Structural strains of tau protein classify diseases
In diseases called tauopathies, misfolded tau proteins form aggregates called fibrils. Fibrils from nine different tauopathies show that tau misfolds in many ways, enabling the diseases to be classified according to fibril structure. ...
2021Gold nanoparticles as a new tool in amyloid studies
The misfolding and self-assembly of proteins into fibrils is a hallmark of several neurodegenerative and systemic diseases. These disease-associated proteins have the propensity to form fibrils with a cross-β sheet structure, called amyloids. Amyloids can ...
EPFL2020Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment
Matthias Lütolf, Olaia Maria Naveiras Torres-Quiroga, Aline Roch, Philipp Sebastian Lienemann, Stéphanie Elisabeth Metzger, Martin Ehrbar, Queralt Vallmajó Martín, Vincent Milleret, Manuel Koch, Panagiota Papageorgiou
The treatment of bone defects with recombinant bone morphogenetic protein-2 (BMP-2) requires high doses precluding broad clinical application. Here, a bioengineering approach is presented that strongly improves low-dose BMP-2-based bone regeneration by mob ...
WILEY2020Muscle co-contraction in an upper limb musculoskeletal model: EMG-assisted vs. standard load-sharing
Dominique Pioletti, Alexandre Terrier, Alain Farron, Philippe Müllhaupt, Ehsan Sarshari, Matteo Mancuso
Estimation of muscle forces in over-actuated musculoskeletal models involves optimal distributions of net joint moments among muscles by a standard load-sharing scheme (SLS). Given that co-contractions of antagonistic muscles are counterproductive in the n ...
TAYLOR & FRANCIS LTD2020Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy
Henning Paul-Julius Stahlberg, Ricardo Cesar Guerrero Ferreira, Pratibha Kumari
Intracellular inclusions rich in alpha-synuclein are a hallmark of several neuropathological diseases including Parkinson’s disease (PD). Previously, we reported the structure of alpha-synuclein fibrils (residues 1–121), composed of two protofibrils that a ...
2019