Concept

Two-component regulatory system

Publications associées (40)

Bioanalytical procedure to detect membrane receptor activation

The invention concerns a method for screening compound interaction with transmembrane receptors involved in cellular signal transduction, preferably with G protein coupled receptors, by adding the compound to be analyzed into a medium comprising native inv ...

2010

GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

Darren Moore

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with late-onset, autosomal-dominant, familial Parkinson's disease (PD) and also contribute to sporadic disease. The LRRK2 gene encodes a large protein with multiple domains, includin ...

Public Library of Science2010

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB

Etienne Meylan, Jessica Christine Vazquez

Detection of viral nucleic acids is central to antiviral immunity. Recently, DAI/ZBP1 (DNA-dependent activator of IRFs/Z-DNA binding protein 1) was identified as a cytoplasmic DNA sensor and shown to activate the interferon regulatory factor (IRF) and nucl ...

2009

The Vibrio cholerae hybrid sensor kinase VieS contributes to motility and biofilm regulation by altering the cyclic diguanylate level

Anna De Graff Tischler

Phosphorelay systems are important mediators of signal transduction during bacterial adaptation to new environments. Previously we described the vieSAB operon, encoding a putative three-protein component phosphorelay involved in regulating Vibrio cholerae ...

2008

Identification of the Design Principles of Signaling Pathways for Metabolic Engineering

Dominique Bonvin, Vassily Hatzimanikatis, Benoît Chachuat, Andrijana Radivojevic

The mitogen-activated protein kinase (MAPK) cascades are ubiquitous in eukaryotic signal transduction, and these pathways are conserved in cells from yeast to mammals. Metabolic engineering of mammalian cells requires the redesign of the steady-sate and th ...

2008

TRADD protein is an essential component of the RIG-like helicase antiviral pathway

Etienne Meylan, Jessica Christine Vazquez

Upon detection of viral RNA, the helicases RIG-I and/or MDA5 trigger, via their adaptor Cardif (also known as IPS-1, MAVS, or VISA), the activation of the transcription factors NF-kappaB and IRF3, which collaborate to induce an antiviral type I interferon ...

2008

Study of Tricyclic Cascade Networks using Dynamic Optimization

Dominique Bonvin, Vassily Hatzimanikatis, Benoît Chachuat, Andrijana Radivojevic

The mitogen-activated protein kinase (MAPK) cascades are ubiquitous in eukaryotic signal transduction, and these pathways are conserved in cells from yeast to mammals. They relay extracellular stimuli from the plasma membrane to targets in the cytoplasm an ...

2008

Understanding the Optimal Response Properties of Tricyclic Cascade Networks through Dynamic Optimization

Dominique Bonvin, Vassily Hatzimanikatis, Benoît Chachuat

2007

Signal transduction networks: topology, response and biochemical processes

Marcel Salathé

Conventionally, biological signal transduction networks are analysed using experimental and theoretical methods to describe specific protein components, interactions, and biochemical processes and to model network behavior under various conditions. While t ...

Elsevier2006

Alveolar and lactogenic differentiation

Cathrin Brisken, Renuga Devi Rajaram

The mouse mammary gland is a complex tissue that proliferates and differentiates under the control of systemic hormones during puberty, pregnancy and lactation. Once a highly branched milk duct system has been established, during mid/late pregnancy, alveol ...

2006

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