Concept

Splénomégalie myéloïde

Publications associées (36)

Treatment with KLEPTOSE (R) CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response

The ability of pharmacological agents to target both "classical" risk factors and inflammation may be key for successful outcomes in the prevention and treatment of atherogenesis. Among the promising drugs interfering with cholesterol metabolism, we invest ...

Elsevier Science Inc2015

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

Eva Sabrina Gollwitzer, Nicola Harris, Benjamin John Marsland

Metabolites from intestinal microbiota are key determinants of host-microbe mutualism and, consequently, the health or disease of the intestinal tract. However, whether such host-microbe crosstalk influences inflammation in peripheral tissues, such as the ...

Nature Publishing Group2014

Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization

Irène Baccelli

The phosphatase and tumor suppressor PTEN inhibits the phosphoinositol-3-kinase (PI3K) signaling pathway and plays a key role in cell growth, proliferation, survival, and migration. Pten conditional deletion using MxCre or Scl-CreERT leads to splenomegaly ...

Rockefeller Univ Press2013

Phosphopantetheinyl transferase-catalyzed formation of bioactive hydrogels for tissue engineering

Kai Johnsson, Matthias Lütolf, Katarzyna Mosiewicz

Synthetic bioactive hydrogels have been widely recognized as key elements of emerging strategies to engineer tissues. However, the current shortage of highly specific and biocompatible methods to form and functionalize these materials hampers their wide ph ...

American Chemical Society2010

Additive and global functions of HoxA cluster genes in mesoderm derivatives

Denis Duboule, Freddy Radtke, Ute Koch

Hox genes encode transcription factors that play a central role in the specification of regional identities along the anterior to posterior body axis. In the developing mouse embryo, Hox genes from all four genomic clusters are involved in range of develop ...

Elsevier2010

Biomechanical Induction of Hematopoiesis

Olaia Maria Naveiras Torres-Quiroga

The present invention provides methods and compositions for increasing the hematopoietic potential of a population of hematopoietic progenitor cells, vascular cells, and or hemogenic endothelium, by exposing the cells to at least one external biomechanical ...

2010

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of notch signaling in the murine skin

Freddy Radtke, Ute Koch, Matteo Di Piazza

BACKGROUND: The Notch pathway is essential for proper epidermal differentiation during embryonic skin development. Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. ...

Public Library of Science2010

The Ash1L methyltransferase is essential for normal hematopoiesis in the mouse

Histones have essential functions in the regulation of gene expression through epigenetic modifications of their N-terminal tails. Acetylation, methylation, phosphorylation, ubiquitination and other post-translational histone modifications constitute a com ...

2010

The role of TIF1 gamma during adult murine hematopoiesis

Konstantin Shakhbazov

Transforming Growth Factor beta (TGFβ) signaling plays an important role in a variety of cellular processes during embryonic development, adult tissue homeostasis and cancer. TGFβI ligand is a potent inhibitor of early hematopoietic progenitor [1] cells in ...

EPFL2009

The role of MYC in bone and in the hematopoietic stem cell niche

Maike Jaworski

The nuclear protein c-Myc is one of the most potent proto-oncogenes described. Its expression is found to be deregulated in more than 50 percent of human cancers, where it has been shown to control a number of biological processes including driving prolife ...

EPFL2009

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