Concept

Dictyostelium discoideum

Publications associées (13)

Microfluidic Platforms for the Study of Bacterial Metabolism and Antimicrobial Susceptibility Testing

Fast spreading antimicrobial resistance (AMR) is an emerging major public health issue. New therapeutic and diagnostic paradigms must be implemented to counteract this evolution. In this respect, fast antimicrobial susceptibility testing (AST) plays an imp ...

EPFL2021

Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling

Andrea Ablasser, Bing Zhang, Alix Martin, Ensieh Farahani

The innate immune system is crucial for eventual control of infections, but may also contribute to pathology. Listeria monocytogenes is an intracellular Gram-positive bacteria and a major cause of food-borne disease. However, important knowledge on the int ...

NATURE PUBLISHING GROUP2019

A microfluidic cell-trapping device to study dynamic host-microbe interactions at the single-cell level

John McKinney, Matthieu Jean-Hubert Delincé, Chiara Toniolo

Single-cell imaging of host-microbe interactions over time is impeded by cellular motility because the cells under scrutiny tend to migrate out of the imaging field. To overcome this technical challenge, we developed a microfluidic platform for imaging hun ...

ELSEVIER ACADEMIC PRESS INC2018

Bacterial type VI secretion system facilitates niche domination

Melanie Blokesch, Natalia Carolina Drebes Dorr

Over the last few decades humanity has experienced a series of tremendous technological advances, especially in the realm of basic science. A plethora of new approaches has allowed us to appreciate life in previously unimaginable detail, prompting the real ...

2018

A microfluidic cell-trapping device for single-cell tracking of host-microbe interactions

John McKinney, Jean-Baptiste Bureau, Matthieu Jean-Hubert Delincé, Thierry Soldati

The impact of cellular individuality on host-microbe interactions is increasingly appreciated but studying the temporal dynamics of single-cell behavior in this context remains technically challenging. Here we present a microfluidic platform, InfectChip, t ...

Royal Society of Chemistry2016

Quantitative Single-Cell Analysis of Host-Pathogen Interactions

Matthieu Jean-Hubert Delincé

During infection, microbial pathogens encounter phagocytic cells of the host innate immune system, such as macrophages and neutrophils. These encounters typically lead to uptake and killing of the bacteria by the host cell or, conversely, parasitization of ...

EPFL2016

Minimal model for spontaneous cell polarization and edge activity in oscillating, rotating and migrating cells

Jean-Jacques Meister, Chiara Gabella, Franck Claude Raynaud, Alicia Carine Bornert

How cells break symmetry and organize activity at their edges to move directionally is a fundamental question in cell biology. Physical models of cell motility commonly incorporate gradients of regulatory proteins and/or feedback from the motion itself to ...

Nature Publishing Group2016

Fundamental Constraints on the Abundances of Chemotaxis Proteins

Anne-Florence Raphaëlle Bitbol

Flagellated bacteria, such as Escherichia coli, perform directed motion in gradients of concentration of attractants and repellents in a process called chemotaxis. The E. coli chemotaxis signaling pathway is a model for signal transduction, but it has uniq ...

Elsevier BV2015

Are motorways rational from slime mould's point of view ?

Emanuele Strano

We analyse the results of our experimental laboratory approximation of motorways networks with slime mould Physarum polycephalum. Motorway networks of fourteen geographical areas are considered: Australia, Africa, Belgium, Brazil, Canada, China, Germany, I ...

2012

An agarose-based microfluidic platform with a gradient buffer for 3D chemotaxis studies

Melody Swartz, Ulrike Haessler, Mingming Wu

The current state-of-art in 3D microfluidic chemotaxis device (mu FCD) is limited by the inherent coupling of the fluid flow and chemical concentration gradients. Here, we present an agarose-based 3D mu FCD that decouples these two important parameters, in ...

Springer Verlag2009

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