Quantum sensor | EPFL Graph Search

Within quantum technology, a quantum sensor utilizes properties of quantum mechanics, such as quantum entanglement, quantum interference, and quantum state squeezing, which have optimized precision and beat current limits in sensor technology. The field of quantum sensing deals with the design and engineering of quantum sources (e.g., entangled) and quantum measurements that are able to beat the performance of any classical strategy in a number of technological applications. This can be done with photonic systems or solid state systems. Characteristics In photonics and quantum optics, photonic quantum sensing leverages entanglement, single photons and squeezed states to perform extremely precise measurements. Optical sensing makes use of continuously variable quantum systems such as different degrees of freedom of the electromagnetic field, vibrational modes of solids, and Bose–Einstein condensates. These quantum systems can be probed to characterize an un

Novel materials and algorithms for quantum technologies

Francesco Libbi

The enormous advancements in the ability to detect and manipulate single quantum states have lead to the emerging field of quantum technologies. Among these, quantum computation is the most far-reaching and challenging, aiming to solve problems that the classic computers could never address because of the exponential scaling, while quantum sensing exploits the ability to address single quantum states to realize ultra-sensitive and precise detectors. Defect centers in semiconductors play a primary role in these fields. The possibility to store information in the spin of their ground state, manipulate it through microwaves, and read it optically allows to use them as qubits. In addition, the very sharp dependence of their properties on temperature, strain and magnetic fields makes them very promising quantum sensors. In this Thesis we aim at contributing to the progress of quantum technologies both at the hardware and software level. From a hardware point of view, we study a key property of defect centers in semiconductors, the phonon-assisted luminescence, which can be measured to perform the readout of the information stored in a quantum bit, or to detect temperature variations. We predict the luminescence and study the exciton-phonon couplings within a rigorous many-body perturbation theory framework,an analysis that has never been performed for defect centers.In particular, we study the optical emission of the negatively-charged boron vacancy in 2D hexagonal boron nitride, which currently stands out among defect centers in 2D materials thanks to its promise for applications in quantum information and quantum sensing. We show that phonons are responsible for the observed luminescence, which otherwise would be dark due to symmetry. We also show that the symmetry breaking induced by the static Jahn-Teller effect is not able to describe the presence of the experimentally observed peak at 1.5 eV.The knowledge of the coupling between electrons and phonons is fundamental for the accurate prediction of all the features of the photoluminescence spectrum. However, the large number of atoms in a defect supercell hinders the possibility use density functional perturbation theory to study this coupling. In this work we present a finite-differences technique to calculate the electron-phonon matrix elements, which exploits the symmetries of the defect in such a way to use the very same set of displacement needed for the calculation of phonons. The computation of electron-phonon coupling thus becomes a simple post-processing of the finite-differences phonons calculation. On the quantum software side, we propose an improved quantum algorithm to calculate the Green's function through real-time propagation, and use it to compute the retarded Green's function for the 2-, 3- and 4-site Hubbard models. This novel protocol significantly reduces the number of controlled operations when compared to those previously suggested in literature. Such reduction is quite remarkable when considering the 2-site Hubbard model, for which we show that it is possible to obtain the exact time propagation of the

\ket{N\pm 1}

states by exponentiating one single Pauli component of the Hamiltonian, allowing us to perform the calculations on an actual superconducting quantum processor.

EPFL2022

Quantitative and sensitive detection of alpha fetoprotein in serum by a plasmonic sensor

Wen Chen, Tianzong Zhang

Quantitative molecular detection based on surface-enhanced Raman spectroscopy (SERS) is still a great challenge because of the highly nonuniform distribution of the SERS hot spots and the nondeterministic spatial and spectral overlap of the analyte with the hot spot. Here, we report a nanoparticle-on-mirror plasmonic sensor excited by surface plasmon polaritons for quantitative SERS detection of alpha fetoprotein in serum with ultrahigh sensitivity. The uniform gaps between the nanoparticles and gold film and the alignment of the gap modes relative to the excitation electric field endow this substrate with a uniform and strong SERS enhancement. The limit of detection reaches 1.45 fM, 697 times higher than that under normal excitation and 7800 times higher than a commercial enzyme-linked immunosorbent assay kit. This approach offers a potential solution to overcome the bottleneck in the field of SERS-based biosensing.

WALTER DE GRUYTER GMBH2022

Quantum Sensing of Free Radicals in Primary Human Dendritic Cells

Mayeul Sylvain Chipaux

Free radicals are crucial indicators for stress and appear in all kinds of pathogenic conditions, including cancer, cardiovascular diseases, and infection. However, they are difficult to detect due to their reactivity and low abundance. We use relaxometry for the detection of radicals with subcellular resolution. This method is based on a fluorescent defect in a diamond, which changes its optical properties on the basis of the magnetic surroundings. This technique allows nanoscale MRI with unprecedented sensitivity and spatial resolution. Recently, this technique was used inside living cells from a cell line. Cell lines differ in terms of endocytic capability and radical production from primary cells derived from patients. Here we provide the first measurements of phagocytic radical production by the NADPH oxidase (NOX2) in primary dendritic cells from healthy donors. The radical production of these cells differs greatly between donors. We investigated the cell response to stimulation or inhibition.

AMER CHEMICAL SOC2021

Novel materials and algorithms for quantum technologies

Francesco Libbi

\ket{N\pm 1}

states by exponentiating one single Pauli component of the Hamiltonian, allowing us to perform the calculations on an actual superconducting quantum processor.

EPFL2022