Concept

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Publications associées (32)

Duplications of hox gene clusters and the emergence of vertebrates

The vertebrate body plan is characterized by an increased complexity relative to that of all other chordates and large-scale gene amplifications have been associated with key morphological innovations leading to their remarkable evolutionary success. Here, ...

Academic Press Inc Elsevier Science2013

The C57BL/6J Mouse Exhibits Sporadic Congenital Portosystemic Shunts

Rolf Gruetter, Cristina Ramona Cudalbu, João Miguel das Neves Duarte, Hongxia Lei

C57BL/6 mice are the most widely used strain of laboratory mice. Using in vivo proton Magnetic Resonance Spectroscopy (1H MRS), we have repeatedly observed an abnormal neurochemical profile in the brains of both wild-type and ge ...

Public Library of Science2013

Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering

Matthias Lütolf, Jeffrey Alan Hubbell

A review. New generations of synthetic biomaterials are being developed at a rapid pace for use as three-dimensional extracellular microenvironments to mimic the regulatory characteristics of natural extracellular matrixes (ECMs) and ECM-bound growth facto ...

2005

Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate

Anne Grapin-Botton, Mithlesh Kumar

During embryonic development, organs arise along the gut tube as a series of buds in a stereotyped anterior-posterior (A-P) pattern. Using chick-quail chimeras and in vitro tissue recombination, we studied the interactions governing the. induction and main ...

2003

Development and diseases of the pancreas

Anne Grapin-Botton

The pancreas is a vital gland of exocrine and endocrine function. It is the target of two main affections: diabetes and pancreatic cancer. We describe the tissue interactions, signaling pathways and intracellular targets that are involved in the emergence ...

2002

On the evolution of some endoscopic light delivery systems for photodynamic therapy

Hubert van den Bergh

Progress in photodynamic therapy (PDT) depends on the development of: (1) photosensitizers, (2) optical devices among which are lasers and light delivery systems, and (3) clinical procedure. The light delivery systems which are the focus of this article ar ...

1998

Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons

Daniel Constam

The puromycin-sensitive aminopeptidase (PSA) is thought to contribute to the degradation of enkephalins. Besides being the most abundant aminopeptidase in the brain, PSA is expressed in other organs as well. From a human fetal brain cDNA library, we have i ...

Wiley-Blackwell1997

Photodetection of early cancer by laser induced fluorescence of a tumor-selective dye: apparatus design and realization

Hubert van den Bergh, Christian Depeursinge, Georges Wagnières, André Châtelain

An apparatus is designed and realized to detect "early" cancer at the surface of the hollow organs in the human body by endoscopic means. The tumor is localized by the laser induced fluorescence of a dye (HPD) which concentrates selectively in the neoplast ...

1990

Photodetection and photodynamic therapy of "early" squamous cell carcinomas of the pharynx, oesophagus and tracheo-bronchial tree

Hubert van den Bergh, Christian Depeursinge, Georges Wagnières, André Châtelain

The efficacy of photodynamic therapy (PDT) alone was evaluated on 41 ‘early’ squamous cell carcinomas of the pharynx (10), oesophagus (15) and tracheo-bronchial tree (16). All lesions but two were synchronous second primaries in ENT-patients suffering from ...

1990

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