Publications associées à Taux de mutation

A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance

Jeffrey David Jensen, Claudia Bank, Li Jiang

The therapeutic benefits of the neuraminidase (NA) inhibitor oseltamivir are dampened by the emergence of drug resistance mutations in influenza A virus (IAV). To investigate the mechanistic features that underlie resistance, we developed an approach to qu ...

Academic Press Ltd- Elsevier Science Ltd2016

The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects

Bruno Lemaitre, Maroun Bou Sleiman, Olivier Binggeli, Lise Bertin

Melanization contributes to arthropod-specific innate immunity through deposition of melanin at wound sites or around parasites, with concomitant release of microbicidal reactive oxygen species. Melanization requires sequential activation of proteolytic en ...

Elsevier2015

Second-Order Rate Region of Constant-Composition Codes for the Multiple-Access Channel

Jonathan Mark Scarlett, Albert Guillén i Fàbregas

This paper studies the second-order asymptotics of coding rates for the discrete memoryless multiple-access channel (MAC) with a fixed target error probability. Using constant-composition random coding, coded time-sharing, and a variant of Hoeffding's comb ...

Ieee-Inst Electrical Electronics Engineers Inc2015

Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-beta-D-ribose Oxidase

John McKinney, Neeraj Dhar

We have targeted the Mycobacterium tuberculosis decaprenylphosphoryl-beta-D-ribose oxidase (Mt-DprE1) for potential chemotherapeutic intervention of tuberculosis. A multicopy suppression strategy that overexpressed Mt-DprEl in M. bovis BCG was used to prof ...

Amer Chemical Soc2015

A Systematic Survey of an Intragenic Epistatic Landscape

Jeffrey David Jensen, Claudia Bank

Mutations are the source of evolutionary variation. The interactions of multiple mutations can have important effects on fitness and evolutionary trajectories. We have recently described the distribution of fitness effects of all single mutations for a nin ...

Oxford Univ Press2015

The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome

Jacques Fellay, Amalio Telenti, Istvan Bartha, Nimisha Chaturvedi

Sequencing projects have identified large numbers of rare stop-gain and frameshift variants in the human genome. As most of these are observed in the heterozygous state, they test a gene's tolerance to haploinsufficiency and dominant loss of function. We a ...

Public Library Science2015

Limits and patterns of cytomegalovirus genomic diversity in humans

Jeffrey David Jensen, Cornelia Pokalyuk

Human cytomegalovirus (HCMV) exhibits surprisingly high genomic diversity during natural infection although little is known about the limits or patterns of HCMV diversity among humans. To address this deficiency, we analyzed genomic diversity among congeni ...

Natl Acad Sciences2015

Tmc gene therapy restores auditory function in deaf mice

Patrick Aebischer, Bernard Schneider, Cylia Cloé Rochat

Genetic hearing loss accounts for up to 50% of prelingual deafness worldwide, yet there are no biologic treatments currently available. To investigate gene therapy as a potential biologic strategy for restoration of auditory function in patients with genet ...

American Association for the Advancement of Science2015

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Taux de mutation

A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance

Identifying mutations in Tunisian families with retinal dystrophy

The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects

Second-Order Rate Region of Constant-Composition Codes for the Multiple-Access Channel

Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-beta-D-ribose Oxidase

A Systematic Survey of an Intragenic Epistatic Landscape

The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome

Catch Me if You Can: Adaptation from Standing Genetic Variation to a Moving Phenotypic Optimum

Limits and patterns of cytomegalovirus genomic diversity in humans

Tmc gene therapy restores auditory function in deaf mice

Graph Chatbot

Chattez avec Graph Search

The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome

Tmc gene therapy restores auditory function in deaf mice

The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects

A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance

Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-beta-D-ribose Oxidase

Limits and patterns of cytomegalovirus genomic diversity in humans

Identifying mutations in Tunisian families with retinal dystrophy

Catch Me if You Can: Adaptation from Standing Genetic Variation to a Moving Phenotypic Optimum

Second-Order Rate Region of Constant-Composition Codes for the Multiple-Access Channel