Concept
Vector (molecular biology)
Publications associées (181)
Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6
Patrick Aebischer, Bernard Schneider, Christopher Towne
Retrograde transport of viral vectors in the rodent spinal cord provides a powerful means to administer a therapeutic transgene from the innervated musculature. With the aim of scaling up this approach to non-human primates, we have injected recombinant ad ...
2010The Interplay between Cytidine Deaminases, HIV and Domesticated Genetic Parasites
"There is more virus in us than us in us". John Coffin's famous sentence illustrates that particular nucleic acid sequences related to exogenous viruses, called retrotransposons, constitute almost half of the human genome and largely exceeds the amount of ...
EPFL2010Lentiviral Vector-Mediated Gene Delivery for the Generation of Chinese Hamster Ovary Cell Lines with Improved Productivity and Stability
Recombinant cell line generation by standard transfection techniques is a time-consuming and labor-intensive process often leading to an unpredictable outcome as transgene integration is a rare, random event. Consequently, the population of cells obtained ...
EPFL2010Modeling Parkinson's Disease in Adult Rats Using Viral Vectors as Gene Delivery Tools
Animal models of human pathologies remain invaluable tools for unraveling disease mechanisms and evaluating potential therapeutic strategies. For a number of diseases, the lack of a reliable animal model represents an important limiting step towards the de ...
EPFL2010