Concept
Épithélium intestinal
Publications associées (32)
Characterization of the gut-bone marrow axis through bile acid signaling
Communication between the intestine and other organs such as the lungs, brain or bones is mediated by several metabolites, like short-chain fatty acids or bile acids, that relay information about nutritional and microbiota status. Bile acids are endogenous ...
EPFL2024Engineering hydrogel microenvironments for epithelial organoid culture
Organoids, miniature tissues generated from self-organizing stem cells within three-dimensional (3D) extracellular matrices (ECM), have opened up exciting possibilities for in vitro studies of complex physiological processes. A key factor in the success of ...
EPFL2024Innovative Biomarkers for Obesity and Type 1 Diabetes Based on Bifidobacterium and Metabolomic Profiling
Stephan Morgenthaler, Paul Refinetti, Mariya Yuryevna Skvortsova
The role of Bifidobacterium species and microbial metabolites such as short-chain fatty acids (SCFAs) and human milk oligosaccharides in controlling intestinal inflammation and the pathogenesis of obesity and type 1 diabetes (T1D) has been largely studied ...
MDPI2024Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions
Traditional cell cultures have long been fundamental to biological research, offering an alternative to animal models burdened by ethical constraints and procedural intricacies, often lacking relevance to human physiology and disease. Moreover, their inabi ...
EPFL2024Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease
Hilal Lashuel, Florian Lang, Joan Romani Aumedes, Yogesh Singh
Background Braak's hypothesis states that sporadic Parkinson's disease (PD) follows a specific progression of pathology from the peripheral to the central nervous system, and this progression can be monitored by detecting the accumulation of alpha-Synuclei ...
BMC2023Microfluidic devices for automated analysis of ingested bacteria in the Caenorhabditis elegans intestine
In this thesis, we explored on-chip high-resolution imaging of the fate of intestinal bacteria and bacterial products in Caenorhabditis elegans (C. elegans). In the first part, we carried out high-resolution z-stack fluorescent imaging of Red Fluorescent P ...
EPFL2023Methanobrevibacter smithii ( m. smithii) for use as a biomarker and in the diagnosis and the treatment of disorders associated with aberrant microbiota and/or archaea-deficiency
The present invention generally relates to the field of intestinal health, disorders associated with aberrant microbiota and/or archaea-deficiency, and early-life immune system development. The present invention more specifically relates to M. smithii and ...
2023Identifying genetic and dietary modulators of metabolic disorders using systems genetics
Long-term consumption of lipid-rich foods can contribute to common metabolic diseases and systemic low-grade inflammation. However, dietary responses and the development of non-communicable diseases are shaped by genetic factors and gene-by-environment int ...
EPFL2023Bioengineering human mini-intestines with in vivo-like complexity and function
Biological research heavily relies on the use of animal models, which has made it difficult to answer specific questions about human biology and disease. However, with the advent of human organoids - miniature versions of tissues generated in 3D human stem ...
EPFL2023Bioaccessibility, bioaccumulation and effects of tire-associated chemicals for aquatic and soil-dwelling organisms
Kristin Schirmer, Florian Frédéric Vincent Breider, Benoît Jean Dominique Ferrari, Thibault Béranger Masset
Tire and road wear particles (TRWP) are produced by the friction between the tires and road and consist of polymer-containing tread with pavement encrustations. There are many data gaps remaining regarding their fate and potential toxicological impact on t ...
2022