Concept

Électrophysiologie

Publications associées (375)

Emergent Properties of in silico Synaptic Transmission in a Model of the Rat Neocortical Column

The cerebral cortex occupies nearly 80% of the entire volume of the mammalian brain and is thought to subserve higher cognitive functions like memory, attention and sensory perception. The neocortex is the newest part in the evolution of the cerebral corte ...

EPFL2011

Assessing the cellular uptake pathway for poly-Lysine analogues using triplet lifetime imaging

Dimitri Nestor Alice Van De Ville, Theo Lasser, Harm-Anton Klok, Iwan Märki, Zuzana Kadlecova

Research on synthetic delivery vectors is of major interest for cell imaging and manipulation, as they allow an efficient transfer of nucleic acids, therapeutic proteins or small drugs into the cells. We have developed a library of L-lysine analogues that ...

2011

Synaptic Mechanisms Underlying Sparse Coding of Active Touch

Carl Petersen, Sylvain Crochet, Yves Emile Alfred Kremer, James Poulet

Sensory information is actively gathered by animals, but the synaptic mechanisms driving neuronal circuit function during active sensory processing are poorly understood. Here, we investigated the synaptically driven membrane potential dynamics during acti ...

2011

Characterization of Atrial Repolarization Alternans and Activation Time Kinetics based on Intracardiac Electrograms

Florian Jousset

Interdisciplinary collaboration between physicians and engineers is now widespread in fundamental and clinical studies, due to the increasing complexity of the physiological problems tackled, and the development of novel measurement devices and data analys ...

EPFL2011

Engineering Neuron Models

Rajnish Ranjan

The neocortex is one of the most evolved and complex region of the brain. For more than a century scientists have been curious about the neocortex, to identify the anatomical blueprint of its cellular organization and to understand its role in higher brain ...

EPFL2011

Synaptotagmin increases the dynamic range of synapses by driving Ca2+ - evoked release and by clamping a near-linear remaining Ca2+ sensor

Ralf Schneggenburger, Olexiy Kochubey

Ca2+-evoked transmitter release shows a high dynamic range over spontaneous release. We investigated the role of the Ca2+ sensor protein, Synaptotagmin2 (Syt2), in both spontaneous and Ca2+-evoked release under direct control of presynaptic Ca2+, usin ...

2011

Chaotic mixing using source-sink microfluidic flows in a PDMS chip

Martinus Gijs, Abdeljalil Sayah, Caroline Vandevyver, Hüseyin Cumhur Tekin, Ata Tuna Ciftlik, Venkataragavalu Sivagnanam

We present an active fixed-volume mixer based on the creation of multiple source–sink microfluidic flows in a polydimethylsiloxane (PDMS) chip without the need of external or internal pumps. To do so, four different pressure-controlled actuation chambers a ...

Springer-Verlag2011

Microchannel electrode interfaces to assess bladder afferent activity

Stéphanie Lacour

By placing axons into polymeric microchannels hosting embedded electrodes the extracellular amplitude of action potentials is greatly increased, allowing for robust recording and noise suppression. We are developing such an electrode interface to record el ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2011

Biosensor microprobes with integrated microfluidic channels for bi-directional neurochemical interaction

Nico de Rooij, Peter Van der Wal, Olivier Frey

This paper reports on silicon-based microprobes, 8 mm long and 250 mu m x 250 mu m cross-section, comprising four recessed biosensor microelectrodes (50 mu m x 150 mu m) per probe shank coated with an enzymatic layer for the selective detection of choline ...

2011

Dispensing and Hermetic Sealing Rb in a Miniature Reference Cell for Integrated Atomic Clocks

Herbert Shea, Peter Ryser, Thomas Maeder, Fabrizio Vecchio, Vinu Lalgudi Venkatraman

An innovative method for filling and sealing the reference cell for a Rubidium (Rb) integrated atomic clock is presented. We used a simple, low-temperature solder sealing technique for producing mini-cells of the size of 12 x 10 x 2 mm, suitable for Rb min ...

Elsevier2011

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