Concept
Recombinaison génétique
Publications associées (143)
A chemical biology approach to decipher chromatin ubiquitylation by RNF168
DNA damage signaling following DNA double-strand breaks (DSBs) involves numerous regulating proteins, which dynamically recognize ('read') and alter ('write' or 'erase') histone post-translational modifications (PTMs). Among these PTMs, the ubiquitin syste ...
EPFL2024Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial
PURPOSE The PNOC001 phase II single-arm trial sought to estimate progression-free survival (PFS) associated with everolimus therapy for progressive/recurrent pediatric low-grade glioma (pLGG) on the basis of phosphatidylinositol 3-kinase (PI3K)/AKT/mammali ...
2023Regulation and impact of TERRA R-loops at human telomeres
Telomeres are the nucleoprotein structures found at the ends of linear chromosomes. They ensure that the termini of chromosomes are not inappropriately recognized as sites of DNA damage, and are therefore crucial for genome stability. In spite of the heter ...
EPFL2023Preomic profile of BxPC-3 cells after treatment with BRC4
BRCA2 and RAD51 are two proteins that play a central role in homologous recombination (HR) and DNA double strand break (DSB) repair. BRCA2 assists RAD51 fibrillation and defibrillation through binding with its eight BRC repeats, with BRC4 being one of the ...
ELSEVIER2023Chemical Trend of Nonradiative Recombination in Cu(In,Ga)Se2 Alloys
Nonradiative recombination in Cu(In,Ga)Se2 (CIGS) solar cells has long been attributed to the antisite defects MCu (M = In, Ga), but the underlying mechanism is still elusive. Using rigorous first-principles calculations, we demonstrate that the antisites ...
AMER PHYSICAL SOC2023Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutS gamma complex
Crossover formation is essential for proper segregation of homologous chromosomes during meiosis. Here, we show that Caenorhabditis elegans cyclin-dependent kinase 2 (CDK-2) partners with cyclin-like protein COSA-1 to promote crossover formation by promoti ...
NATL ACAD SCIENCES2022Identification and characterization of proteins that protect human telomeres from fragility
Difficulties to replicate telomeres - the ends of our chromosomes - can cause telomere shortening andgenome instability. These difficulties are due to the repetitive DNA sequence and distinct structures at telomeresthat challenge the semi-conservative DNA ...
EPFL2022Nonequilibrium quasistationary spin disordered state in ?-RuCl3
We photoexcite high-energy holon-doublon pairs as a way to alter the magnetic free energy landscape and resulting phase diagram of the frustrated honeycomb magnet ??-RuCl3. The pair recombination through multimagnon emission is tracked through the time evo ...
AMER PHYSICAL SOC2022Engineering of chitosan-based derivatives for non-viral gene delivery
Gene therapy offers the possibility to treat or even cure diseases originating from genetic defects by introducing a therapeutic gene in target cells or correcting the initial defective gene. Amongst different options, non-viral vectors rely on the deliver ...
EPFL2022