Pierre-André FarinePierre-André Farine received the Doctoral and Engineering Degrees in Microtechnology from University of Neuchâtel, Switzerland, respectively in 1984 and 1978, and the Engineering in Microtechnology from ETS Le Locle in 1974.
He was working 17 years for the Swiss watch industries (Swatch Group), including developments for high-tech products, such as pager watches, watches including integrated sensors such as pressure, compass, altimeter and temperature sensors for Tissot. He was also involved in prototypes developments for watches including GPS and cellular GSM phones.
Since 8 years, he is Professor in Electronics and Signal Processing at the Institute of Microtechnology IMT, University of Neuchâtel, Switzerland. Full professor at EPFL since January 1st, 2009, he works in the field of low-power integrated products for portable devices, including microelectronics for wireless telecommunications, UWB and GNSS systems. He is Head of the Electronics and Signal Processing Laboratory ESPLAB of the EPFL IMT-NE. His laboratory works also for video and audio compression algorithms and their implementation in low power integrated circuits.
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Drazen DujicDrazen Dujic is an Associate Professor and Head of the Power Electronics Laboratory at EPFL. He received the Dipl.Ing. and MSc degrees from the University of Novi Sad, Serbia in 2002 and 2005, respectively, and the PhD degree from Liverpool John Moores University, UK in 2008. From 2003 to 2006, he was a Research Assistant with the Faculty of Technical Sciences at University of Novi Sad. From 2006 to 2009, he was a Research Associate with Liverpool John Moores University. After that he moved to industry and joined ABB Switzerland Ltd, where from 2009 to 2013, he was Scientist and then Principal Scientist with ABB Corporate Research Center in Baden-Dättwil, and from 2013 to 2014 he was R&D Platform Manager with ABB Medium Voltage Drives in Turgi. He joined EPFL in 2014 as Tenure Track Assistant Professor and was promoted to Associate Professor in 2021. His research interests include the areas of design and control of advanced high power electronic systems and high-performance drives, predominantly for the medium voltage applications related to electrical energy generation, conversion and storage. He has authored or coauthored more than 150 scientific publications and has filed 16 patents. In 2018 he received EPE Outstanding Service Award from European Power Electronics and Drives Association and in 2014 the Isao Takahashi Power Electronics Award for Outstanding Achievement in Power Electronics. He is Senior Member of IEEE, and serves as Associate Editor for IEEE Transactions on Power Electronics, IEEE Transactions on Industrial Electronics and IET Electric Power Applications. He is Chairman of the Swiss IEEE Power Electronics Society (PELS) Chapter and IEEE PELS R8 Chair.
Paolo IennePaolo Ienne has been a Professor at the EPFL since 2000 and heads the Processor Architecture Laboratory (LAP). Prior to that, he worked for the Semiconductors Group of Siemens AG, Munich, Germany (which later became Infineon Technologies AG) where he was at the head of the Embedded Memories unit in the Design Libraries division. His research interests include various aspects of computer and processor architecture, FPGAs and reconfigurable computing, electronic design automation, and computer arithmetic. Ienne was a recipient of Best Paper Awards at the 20th, 24th, and 28th ACM/SIGDA International Symposia on Field-Programmable Gate Arrays (FPGA), in 2012, 2016 and 2020, at the 19th and 30th International Conference on Field-Programmable Logic and Applications (FPL), in 2009 and 2020, at the International Conference on Compilers, Architectures, and Synthesis for Embedded Systems (CASES), in 2007, and at the 40th Design Automation Conference (DAC), in 2003; many other papers have been candidates to Best Paper Awards in prestigious venues. He has served as general, programme, and topic chair of renown international conferences, including organizing in Lausanne the 26th International Conference on Field-Programmable Logic and Applications (FPL) in 2016. He serves on the steering committee of the IEEE Symposium on Computer Arithmetic (ARITH) and of the International Conference on Field-Programmable Logic and Applications (FPL). Ienne has guest edited a number of special issues and special sections on various topics for IEEE and ACM journals. He is regularly member of program committees of international workshops and conferences in the areas of design automation, computer architecture, embedded systems, compilers, FPGAs, and asynchronous design. He has been an associate editor of ACM Transactions on Architecture and Code Optimization (TACO), since 2015, of ACM Computing Surveys (CSUR), since 2014, and of ACM Transactions on Design Automation of Electronic Systems (TODAES) from 2011 to 2016.
Dario FloreanoProf. Dario Floreano is director of the Laboratory of Intelligent Systems at the Swiss Federal Institute of Technology Lausanne (EPFL). Since 2010, he is the founding director of the Swiss National Center of Competence in Robotics, a research program that brings together more than 20 labs across Switzerland. Prof. Floreano holds an M.A. in Vision, an M.S. in Neural Computation, and a PhD in Robotics. He has held research positions at Sony Computer Science Laboratory, at Caltech/JPL, and at Harvard University. His main research interests are Robotics and A.I. at the convergence of biology and engineering. Prof. Floreano made pioneering contributions to the fields of evolutionary robotics, aerial robotics, and soft robotics. He served in numerous advisory boards and committees, including the Future and Emerging Technologies division of the European Commission, the World Economic Forum Agenda Council, the International Society of Artificial Life, the International Neural Network Society, and in the editorial committee of several scientific journals. In addition, he helped spinning off two drone companies (senseFly.com and Flyability.com) and a non-for-profit portal on robotics and A.I. (RoboHub.org). Books
Manuale sulle Reti Neurali, il Mulino (in Italian), 1996 (first edition), 2006 (second edition)Evolutionary Robotics, MIT Press, 2000
Bio-Inspired Artificial Intelligence, MIT Press, 2008
Flying Insects and Robots, Springer Verlag, 2010
