Publications associées à Metabolic engineering

Large Scale Dynamic Models of Metabolism as a Tool for Analysis and Design of Metabolic Engineering and Synthetic Biology Strategies

Vassily Hatzimanikatis, Ljubisa Miskovic, Georgios Fengos

Large-scale dynamic models of metabolism remain an overarching ambition of efforts that aim to analyze and explain complex behavior of living entities. However, intrinsic nonlinearity of dynamics of living organisms and structural and quantitative uncertai ...

2016

“ATLAS of Biochemistry”: A repository of all possible biochemical reactions for synthetic biology, metabolic engineering and metabolomics studies

Vassily Hatzimanikatis, Jasmin Maria Hafner, Adrian Shajkofci, Noushin Hadadi, Aikaterini Zisaki

Recent technical and analytical progress in the field of metabolomics has lead to the identification of vast amounts of new compounds in living organisms. However, the integration of these compounds into the context of known metabolism remains difficult. T ...

2016

Nutritional input from dinoflagellate symbionts in reef-building corals is minimal during planula larval life stage

Anders Meibom, Isabelle Domart-Coulon, Christophe Kopp

Dispersion of larval offspring is of fundamental ecological importance to sessile marine organisms. Photosymbiotic planulae emitted by many reef-forming corals may travel over large distances before settling to form a new colony. It is not clear whether th ...

Amer Assoc Advancement Science2016

Exploring enhancement of 1,4-butanediol production in recombinant E. coli using large-scale kinetic models

Vassily Hatzimanikatis, Ljubisa Miskovic, Keng Cher Soh, Anirikh Chakrabarti, Stefano Andreozzi

Engineering of microbial cell factories requires a simultaneous optimization of several criteria such as productivity, yield, titer, stress tolerance, all the while retaining the efficient, cost-effective and robust process. One of the most prominent examp ...

2015

Automated reconstruction of E-coli metabolic network from labeled metabolites

Vassily Hatzimanikatis, Jasmin Maria Hafner, Noushin Hadadi

Biological pathways have been extensively analyzed and modeled in respect to overall conversions of substrates to products, although information on atom transitions or atom flow in metabolic networks is not available in databases. The reaction atom mapping ...

2015

Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla

Rolf Gruetter, Lijing Xin, Hongxia Lei, Bernard Lanz

(13)C magnetic resonance spectroscopy (MRS) combined with the administration of (13)C labeled substrates uniquely allows to measure metabolic fluxes in vivo in the brain of humans and rats. The extension to mouse models may provide exclusive prospect for t ...

Nature Publishing Group2015

Design of computational retrobiosynthesis tools for the design of de novo synthetic pathways

Vassily Hatzimanikatis, Noushin Hadadi

Designing putative metabolic pathways is of great interest in synthetic biology. Retrobiosynthesis is a discipline that involves the design, evaluation, and optimization of de novo biosynthetic pathways for the production of high-value compounds and drugs ...

Elsevier Sci Ltd2015

A Study of Dynamic Responses of E. coli Metabolism Upon Large Perturbations Using Large-Scale Kinetic Models

Vassily Hatzimanikatis, Ljubisa Miskovic, Georgios Fengos, Milenko Tokic

In recent years, constraint-based approaches have been widely used for analyzing cellular metabolism. These approaches use stoichiometric models for the characterization of the intracellular fluxes at steady state. Nonetheless, the stoichiometric models la ...

2015

A Novel Approach to Design of Metabolic Engineering Strategiesa

Vassily Hatzimanikatis, Ljubisa Miskovic, Meriç Ataman, Georgios Fengos, Keng Cher Soh, Anirikh Chakrabarti

Dynamic nonlinear models of metabolism offer significant advantages as compared to traditional steady-state counterparts for the analysis of metabolic networks and identification of metabolic engineering strategies. Uncertainties in the metabolic network s ...

2014

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Metabolic engineering

Large Scale Dynamic Models of Metabolism as a Tool for Analysis and Design of Metabolic Engineering and Synthetic Biology Strategies

“ATLAS of Biochemistry”: A repository of all possible biochemical reactions for synthetic biology, metabolic engineering and metabolomics studies

Nutritional input from dinoflagellate symbionts in reef-building corals is minimal during planula larval life stage

Exploring enhancement of 1,4-butanediol production in recombinant E. coli using large-scale kinetic models

Automated reconstruction of E-coli metabolic network from labeled metabolites

Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla

Design of computational retrobiosynthesis tools for the design of de novo synthetic pathways

Computational Studies on Cellular Metabolism

A Study of Dynamic Responses of E. coli Metabolism Upon Large Perturbations Using Large-Scale Kinetic Models

A Novel Approach to Design of Metabolic Engineering Strategiesa

Graph Chatbot

Chattez avec Graph Search

Exploring enhancement of 1,4-butanediol production in recombinant E. coli using large-scale kinetic models

Automated reconstruction of E-coli metabolic network from labeled metabolites

Design of computational retrobiosynthesis tools for the design of de novo synthetic pathways

Nutritional input from dinoflagellate symbionts in reef-building corals is minimal during planula larval life stage

“ATLAS of Biochemistry”: A repository of all possible biochemical reactions for synthetic biology, metabolic engineering and metabolomics studies

Large Scale Dynamic Models of Metabolism as a Tool for Analysis and Design of Metabolic Engineering and Synthetic Biology Strategies

Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla

A Novel Approach to Design of Metabolic Engineering Strategiesa

A Study of Dynamic Responses of E. coli Metabolism Upon Large Perturbations Using Large-Scale Kinetic Models

Computational Studies on Cellular Metabolism