Concept
Hépatite B
Publications associées (52)
Host-Pathogen Interactions Through the Genomic Lens
Hosts and pathogens are involved in a long-standing evolutionary arms race characterized by successive rounds of evolution. Specifically, while hosts evolve resistance against infections, pathogens adapt to re-establish virulence. Since the signatures of t ...
EPFL2023Induction of a strong and long-lasting neutralizing immune response by dPreS1-TLR2 agonist nanovaccine against hepatitis B virus
Hepatitis B virus remains a major medical burden with more than 250 million chronically infected patients worldwide and 900,000 deaths each year, due to the disease progression towards severe complications (cirrhosis, hepatocellular carcinoma). Despite the ...
ELSEVIER2023Inborn errors of type I interferon immunity in patients with symptomatic acute hepatitis E
Background and Aims:The clinical spectrum of human infection by HEV ranges from asymptomatic to severe acute hepatitis. Furthermore, HEV can cause diverse neurological manifestations, especially Parsonage-Turner syndrome. Here, we used a large-scale human ...
Philadelphia2023Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipients
Jacques Fellay, Christian Hammer, Nimisha Chaturvedi, Petar Scepanovic, Samira Asgari
Acute liver failure (ALF) or fulminant hepatitis is a rare, yet severe outcome of infection with hepatitis B virus (HBV) that carries a high mortality rate. The occurrence of a life-threatening condition upon infection with a prevalent virus in individuals ...
2019Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes
Jacques Fellay, Nimisha Chaturvedi
Genetic polymorphism in the interferon lambda (IFN-lambda) region is associated with spontaneous clearance of hepatitis C virus (HCV) infection and response to interferon-based treatment. Here, we evaluate associations between IFN-l polymorphism and HCV va ...
ELIFE SCIENCES PUBLICATIONS LTD2019Detection of dicistroviruses RNA in blood of febrile Tanzanian children
Mary-Anne Hartley, Thomas Junier
Fever is the leading cause of paediatric outpatient consultations in Sub-Saharan Africa. Although most are suspected to be of viral origin, a putative causative pathogen is not identified in over a quarter of these febrile episodes. Using a de novo assembl ...
TAYLOR & FRANCIS LTD2019Population density and water balance influence the global occurrence of hepatitis E epidemics
Stéphane Joost, Anna Carratala Ripolles
In developing countries, the waterborne transmission of hepatitis E virus (HEV), particularly the genotypes 1 and 2, leads to the onset of large recurrent outbreaks. In order to identify the geographical regions at higher risk of HEV epidemics and the cond ...
2018